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NEW YORK (GenomeWeb) – A new prostate cancer analysis suggests tumors from African American men are more likely to carry gene splicing variants associated with tumor aggressiveness and poor outcomes than tumors from European Americans.

Researchers from George Washington University and elsewhere used array-based expression profiling to uncover differential splicing events in prostate cancer samples from 20 African American and 15 European American men — a search that led to thousands of candidate splice variants that were differentially expressed depending on ancestry.

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