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New Product Watch: Apr 27, 2010


Affymetrix this week launched its Axiom Genome-Wide ASI Array. The chip was designed to support genome-wide association studies in East Asian populations, and is the second catalog release for the company's Axiom Genotyping Solution. The firm said other population-focused arrays for GWA studies will debut later this year.

The Axiom Genome-Wide ASI Array enables researchers to characterize the genetic basis of disease in Asian populations and also offers high genomic coverage for Caucasian populations, making it a powerful, high-throughput tool for ancestry, population, and personal genomic studies, the company said.

The Genome-Wide ASI Array covers known disease association markers; chromosomes X and Y; mitochondrial genomes; and genes associated with absorption, distribution, metabolism, and excretion. Content for the array was drawn from the 1000 Genomes Project as well as Han Chinese and Tokyo Japanese data made available through the International HapMap Project, Affy said.

Febit this week updated its Geniom miRNA Biochip to reflect the content in miRBase version 15. Hosted by the University of Manchester in the UK, miRBase version 15 was also released this week.

The fifteenth release of the database contains over 3,000 new hairpin sequences and more than 4,000 new mature sequences, Febit said. Altogether, miRBase 15 contains 14,197 entries representing hairpin precursor miRNAs, expressing 15,632 mature miRNA products, in 133 species. The number of miRNA sequences for Homo sapiens is now 940, the company added.

Febit regularly updates its Geniom Biochips with each release of miRBase, which is typically updated three or four times a year. The biochips are available as customized arrays or using a capture-probe design, the company said.

Fluidigm this week released protocol for its Access Array System that enables sequencing of amplicon libraries using GS FLX Titanium series reagents on the Roche 454 GS FLX sequencing system.

Fluidigm's Access Array integrated fluidic circuit automatically generates emPCR-ready libraries by simultaneously combining 48 samples and 48 primer sets to produce 48 uniquely-barcoded samples per chip for approximately $7 per sample.

Fluidigm said its Access Array IFC, when used with a 454 Titanium sequencer, can capture up to 24 kilobases of sequence data per sample, or 1.15 megabases per IFC.

The Scan

Study Finds Sorghum Genetic Loci Influencing Composition, Function of Human Gut Microbes

Focusing on microbes found in the human gut microbiome, researchers in Nature Communications identified 10 sorghum loci that appear to influence the microbial taxa or microbial metabolite features.

Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Researchers in JAMA Network Open did not find an association between ultimate treatment costs and investments in a drug when they analyzed available data on 60 approved drugs.

Sleep-Related Variants Show Low Penetrance in Large Population Analysis

A limited number of variants had documented sleep effects in an investigation in PLOS Genetics of 10 genes with reported sleep ties in nearly 192,000 participants in four population studies.

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.