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New Product Watch: Aug 30, 2011


Phalanx Biotech has updated its OneArray microRNA expression-profiling microarrays to reflect the content of miRBase version 17. The latest miRBase release includes 2,406 additional mature microRNAs, of which 563 represent newly verified sequences in human, mouse, and rat, Phalanx said. The latest version of the miRNA database was released in April.

Kinexus Bioinformatics recently launched its TranscriptoNet KnowledgeBase for the study of human gene expression in more than 300 types of human tissues and organs as well as more than 300 human cancer cell lines. The open-access resource features information on the mRNA expression levels for almost 23,000 human genes, according to the Vancouver, BC-based company. The original data was retrieved from the National Center for Biotechnology Information's Gene Expression Omnibus database, with special emphasis placed on human tumors and cancer cell lines to identify the differential regulation of genes in cancer. Because of this, Kinexus claims that TranscriptoNet can be used to uncover new potential oncogenes and tumor suppressor genes that may encode cancer protein biomarkers and drug targets.

The new database complements Kinexus' PhosphoNet KnowledgeBase, which tracks more than 650,000 known and putative regulatory phosphorylation sites in human proteins; and the KiNet-Antibody Microarray and KiNet-Immunoblotting Databases, repositories of semi-quantitative proteomics data with antibody probes.

BioDiscovery has released version 6.0 of its Nexus Copy Number software for DNA copy number analysis from comparative genomic hybridization and SNP array data.

Nexus Copy Number version 6 includes the Genomic Identification of Significant Targets in Cancer algorithm for identifying significant regions of common genomic aberrations as well as the Allele-Specific Copy Number Analysis of Tumors algorithm for addressing sample aneuploidy and mosaicism. Other new capabilities provide users with more control over display and reporting and generation of publication quality graphics, BioDiscovery said.

HTG Molecular Diagnostics this week launched its qDiscovery miRNA Whole Transcriptome Array version 16 for microRNA analysis.

The array measures all known human, rat and mouse miRNAs in a single sample well with a quality control tested list of available miRNA genes. It also includes 35 of the top endogenous housekeeping mRNA genes for data normalization, according to the Tucson, Ariz.-based firm. The product is based on HTG's qNPA ArrayPlate platform, which allows researchers to measure miRNA and mRNA simultaneously in the same sample well.

The Scan

Cell Atlas of Human Lung Development Gives View of Developing Airway

Researchers have generated a cell atlas of human lung development, which they report in Cell.

Study Finds Costs of Genome Sequencing May Limit Utility in Routine Care

Researchers report in the European Journal of Human Genetics that genome sequencing for rare disease diagnoses currently has similar benefits as less expensive exome analysis.

Study Suggests Nursing Mother's Diet Can Impact Offspring's Gut Microbiome

A new Cell Host and Microbe paper finds that mice whose mothers were fed a low-fiber diet during nursing experience lasting microbiota dysbiosis and increased obesity.

Study Links Genetic Risk for ADHD With Alzheimer's Disease

A higher polygenic risk score for attention-deficit/hyperactivity disorder is also linked to cognitive decline and Alzheimer's disease, a new study in Molecular Psychiatry finds.