NEW YORK(GenomeWeb) – A team from the Foundation IRCCS National Cancer Institute in Milan has published a proof of concept of a method for capturing and measuring gene expression in circulating tumor cells, which they hope to use in the clinical care of advanced tumors.

In their approach, the researchers coupled magnetic bead-based capture of CTCs, using antibodies against both EpCAM and MUC1, with gene-expression analysis using Illumina's BeadChip-based Whole Genome-DASL HT assay.

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While gene therapies may have high price tags, they could be cheaper than the cost of managing disease, according to MIT's Technology Review.

Researchers are looking for markers that indicate which cancer patients may respond to immunotherapies, the Associated Press writes.

In Nature this week: paternal age associated with de novo mutations in children, and more.

Nature News writes that researchers are still wrangling over the role of the p-value.