The University of California of Oakland has received US Patent No. 8,308,066, "Method for forming optically encoded thin films and particles with grey scale spectra." According to the patent, a semiconductor or insulator substrate is etched to form a thin film including pores. The etching conditions are controlled to vary porosity in the thin film according to a pattern that will generate an optical signature in the reflectivity spectrum in response to illumination such that the optical signature will include a grey scale code.
Agilent Technologies of Santa Clara, Calif., has received US Patent No. 8,309,307, "High resolution chromosomal mapping." The patent relates to spatial and structural genomic analysis compositions, which can be used for the mapping of chromosomes and structural analyses of chromosomal rearrangements, including the entire chromosome, as well as specific portions or regions of interest of the chromosomes. In some embodiments, multiple portions of the genome can be distinguished, for instance, using a first detection entity and a second detection entity different from the first detection entity. According to the patent, the detection entities may be immobilized relative to oligonucleotides, which may be selected to bind to different locations within the chromosome.
BioArray Solutions, now part of Immucor, of Warren, NJ, has received US Patent No. 8,309,368, "Method of making a microbead array with attached biomolecules." The patent provides a set of operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and manipulation of array shape and size. In addition, it enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations, and provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components.
Affymetrix of Santa Clara, Calif., has received US Patent No. 8,309,496, "Methods for photolithographic synthesis of polymer arrays utilizing anti-reflective coatings." The method includes providing a substrate, where the substrate includes an array synthesis surface, and where the array synthesis surface includes functional groups protected by photolabile protecting groups; deprotecting the functional groups with illumination configured to remove the photolabile protecting groups and produce exposed functional groups; coupling monomers to the exposed functional groups within the selected regions, where the monomers are protected by photolabile protecting groups; and repeating these steps with different sets of selected regions to synthesize the array of polymers.