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IP Roundup: Philadelphia Health and Education Corporation, Illumina, Canon, Biosigma, Affymetrix


Philadelphia Health and Education Corporation of Philadelphia has received US Patent No. 8,206,899, "Prostate cancer-related compositions, methods and kits based on DNA microarray proteomics platforms." Methods of detecting and treating prostate cancer are claimed that include modulating or detecting PCADM-1 gene expression and the production and activity of the PCADM-1 polypeptide. Arrays are also claimed for the identification of DNA-binding proteins and the double-stranded oligonucleotide sequences that specifically bind with them. Finally, the patent claims DNA enzymes that specifically bind PCADM-1 mRNA to inhibit PCADM-1 gene expression and destroy tumor cells and tumor tissue.

Illumina of San Diego has received US Patent No. 8,206,917, "Combinatorial decoding of random nucleic acid arrays." A method of identifying a nucleotide in a candidate sequence is claimed. It includes providing an array substrate containing a first subpopulation and a second subpopulation of identifier probes, where both populations are hybridized to detection probes that include a label that distinguishes the detection nucleotides; detecting the presence of the label; dehybridizing the detection probes from said identifier probes; and associating the label with the identity of a nucleotide in the candidate sequence.

Canon of Tokyo has received US Patent No. 8,207,317, "Probe, probe set, probe-immobilized carrier, and genetic testing method." Describes a method of detecting a Campylobacter genus in an analyte by using a probe-immobilized carrier. The method includes reacting the analyte with a probe-immobilized carrier and detecting the presence or absence of a hybridization reaction of the probe set on the probe-immobilized carrier with a nucleic acid in the analyte, or detecting the strength of a hybridization reaction of the probe set on the probe-immobilized carrier with the nucleic acid in the analyte. According to the patent, the presence of the hybridization reaction or the strength of the hybridization reaction indicates the presence of the Campylobacter genus in the analyte.

Biosigma of Colina, Chile, has received US Patent No. 8,207,324, "Array of nucleotidic sequences for the detection and identification of genes that codify proteins with activities relevant in biotechnology present in a microbiological sample, and method for using this array." The described array covers genes that codify for proteins relevant in the biofilm formation, in carbon dioxide fixation, in energetic metabolism, for chemiotaxis and mobility, in iron oxidizing, in nitrogen metabolism, in sulfur assimilation, and in oxidation and reduction of sulfide compounds.

Affymetrix has received US Patent No. 8,208,710, "System, method, and product for scanning of biological materials." The claimed system includes optical elements that direct an excitation beam at a probe array; detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array; a transport frame that adjusts the focusing distance in a direction with respect to the probe array; an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data; and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.

The Scan

Mosquitos Genetically Modified to Prevent Malaria Spread

A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.

Gut Microbiomes Allow Bears to Grow to Similar Sizes Despite Differing Diets

Researchers in Scientific Reports find that the makeup of brown bears' gut microbiomes allows them to reach similar sizes even when feasting on different foods.

Finding Safe Harbor in the Human Genome

In Genome Biology, researchers present a new approach to identify genomic safe harbors where transgenes can be expressed without affecting host cell function.

New Data Point to Nuanced Relationship Between Major Depression, Bipolar Disorder

Lund University researchers in JAMA Psychiatry uncover overlapping genetic liabilities for major depression and bipolar disorder.