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IP Roundup: Georgetown University, Affymetrix


Georgetown University of Washington, DC, has received US Patent No. 8,349,584, "Microarrays and their manufacture." A method is claimed for creating two- and three-dimensional arrays. Plates of sample materials are stacked to create primary stacks. These primary stacks are then sliced to form combs, which are, in turn, stacked to form secondary stacks. The secondary stacks are then sliced to form tertiary plates or two-dimensional arrays. According to the patent, the tertiary plates can also be stacked to form three-dimensional arrays. The two- and three-dimensional arrays can be used in large-scale parallel processing of samples, pattern printing, tissue engineering, microfluidics, microelectronics, and microconstruction, the inventors claim.

Affymetrix of Santa Clara, Calif., has received US Patent No. 8,351,026, "Methods and devices for reading microarrays." A system is claimed for acquiring images of a probe array. It includes a first light-emitting diode that provides light, consisting of a first range of wavelengths outside of an excitation spectrum; a second light-emitting diode that provides light consisting of a second range of wavelengths inside of the excitation spectrum; and a detector that detects one or more wavelengths in the first range of wavelengths, where the first range of wavelengths consists of light wavelengths emitted from fluorescent molecules associated with one or more probes of the probe array in response to the second range of wavelengths and wavelengths reflected from one or more reflective elements associated with the probe array.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.