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IP Roundup: Asuragen, NuGen Technologies, Alere, Affymetrix, University of Colorado


Asuragen of Austin, Texas, has received US Patent No. 8,465,914, "Method and compositions involving microRNA." Methods are claimed for isolating, enriching, and labeling miRNA molecules, and for preparing and using arrays or other detection techniques for miRNA analysis. Methods for generating miRNA profiles and employing such profiles for therapeutic, diagnostic, and prognostic applications are also claimed.

NuGen Technologies of San Carlos, Calif., has received US Patent No. 8,465,950, "Global amplification using a randomly primed composite primer." The patent claims a method for amplification of a template DNA. It includes incubating the template DNA with a pool of first composite primers and a DNA polymerase having strand displacement activity, in order to generate an RNA/DNA heteroduplex. The complex is then incubated with an amplification primer under conditions that permit RNA cleavage, primer hybridization, primer extension, and displacement of the primer extension product, producing multiple copies of a polynucleotide amplification product.

Clondiag, now Alere Technologies, of Jena, Germany, has received US Patent No. 8,467,039, "Device and method for the detection of particles." A device is claimed for the detection of particles. It includes a reaction chamber formed within a chamber body between an opposing first surface and a second surface. According to the patent, a microarray of capture molecules may be disposed on the first surface or the second surface of the reaction chamber.

Affymetrix of Santa Clara, Calif., has received US Patent No. 8,467,974, "System, method, and computer software for the presentation and storage of analysis results." The patent claims a program that processes emission intensity data corresponding to probes of a biological probe array. It includes a genotype and statistical analysis manager that determines absolute or relative expression values based, at least in part, on a statistical measure of the emission intensity data and at least one user-selectable statistical parameter. The analysis manager may also determine genotype calls for one or more probes based, at least in part, on the emission intensity data.

The University of Colorado of Denver has received US Patent No. 8,467,975, "Mixed library parallel gene mapping quantitative microarray technique for genome-wide identification of trait conferring genes." The methods concern quantitative microarray hybridization techniques for genome-wide identification of trait conferring genes. Genetic elements that confer or are associated with a trait are also claimed.

The Scan

Team Tracks Down Potential Blood Plasma Markers Linked to Heart Failure in Atrial Fibrillation Patients

Researchers in BMC Genomics found 10 differentially expressed proteins or metabolites that marked atrial fibrillation with heart failure cases.

Study Points to Synonymous Mutation Effects on E. Coli Enzyme Activity

Researchers in Nature Chemistry saw signs of enzyme activity shifts in the presence of synonymous mutations in a multiscale modeling analysis of three Escherichia coli genes.

Team Outlines Paternal Sample-Free Single-Gene Approach for Non-Invasive Prenatal Screening

With data for nearly 9,200 pregnant individuals, researchers in Genetics in Medicine demonstrate the feasibility of their carrier screening and reflex single-gene non-invasive prenatal screening approach.

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.