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IP Roundup, Apr 19, 2011


Anagnostics of Linz, Austria, has received US Patent No. 7,927,546, "Device for the analysis of liquid samples." The device includes a rotational-symmetric rotor that is inserted into a sample container. An annular gap is provided between the sample container and the rotor, and the rotor has at least one flow channel for transporting liquids and gases into and from the interior of the sample container. A means for a centered mounting of the rotor is also provided.

SRU Biosystems of Woburn, Mass., has received US Patent No. 7,927,789, "Self-referencing biodetection method and patterned bioassays." The patent claims a method of making a self-referencing colorimetric resonant optical biosensor. According to the patent, the biosensor is constructed by immobilizing specific binding substances to a self-referencing colorimetric resonant optical biosensor. The biosensor includes a liquid holding vessel containing a colorimetric resonant optical biosensor as a surface, and a fluid-impermeable divider on the colorimetric resonant optical biosensor surface. According to the patent, the fluid impermeable divider separates the liquid holding vessel into two or more assay regions, one of which serves as a reference region that does not contain immobilized specific binding substances.

SRU Biosystems has also received US Patent No. 7,927,822, "Methods for screening cells and antibodies." A method of detecting a change in a cell growth pattern is claimed. It includes applying cells to the surface of a colorimetric resonant reflectance optical biosensor; incubating the cells for a period of time; detecting colorimetric resonant reflectance optical peak wavelength values (PWVs) for the location continuously over time; and comparing the detected PWVs, where differences between the colorimetric resonant reflectance optical PWVs indicate a change in the cell growth pattern in the one or more cells. According to the patent, the location on a surface of a colorimetric resonant reflectance optical biosensor is an internal surface of a vessel selected from the group consisting of a microtiter well, microtiter plate, test tube, Petri dish, microfluidic channel, and microarray.

Affymetrix of Santa Clara, Calif., has received US Patent No. 7,927,798, "Detection of nucleic acids from whole blood." Methods of detecting nucleic acids from whole blood and from plasma are claimed. In the methods, a sample comprising whole blood is provided. The whole blood includes peripheral blood cells, which are lysed to produce a lysate comprising the first target nucleic acid. The first target nucleic acid is contacted with a first set of capture extenders and hybridized to a solid support. The presence of the first target nucleic acid on the solid support is then detected.

CapitalBio of Beijing has received US Patent No. 7,928,357, "High speed scanning platform for microarray scanner." The described platform uses a flexible metal strip-wheel linear driving system to convert rotary movement of motors into linear movement, driving movement of a stage containing microarrays in the direction of scanning. The platform provides high movement speed, high resolution, and low return deviation, according to the inventors. They also claim it is inexpensive to manufacture.

The Scan

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.

US Survey Data Suggests Ancestry Testing Leads Way in Awareness, Use of Genetic Testing Awareness

Although roughly three-quarters of surveyed individuals in a Genetics in Medicine study reported awareness of genetic testing, use of such tests was lower and varied with income, ancestry, and disease history.

Coral Genome Leads to Alternative Amino Acid Pathway Found in Other Non-Model Animals

An alternative cysteine biosynthesis pathway unearthed in the Acropora loripes genome subsequently turned up in sequences from non-mammalian, -nematode, or -arthropod animals, researchers report in Science Advances.

Mosquitos Genetically Modified to Prevent Malaria Spread

A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.