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IP Roundup: Agilent Technologies, Quanterix, Samsung Electronics, Affymetrix

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Agilent Technologies of Santa Clara, Calif., has received US Patent No. 8,221,978, "Normalization probes for comparative genome hybridization arrays." A method of selecting a set of normalization probes for use on a comparative genome hybridization array is provided. It includes: selecting a first region of a genome to be evaluated by comparative genome hybridization to produce data; selecting a second region of the genome for normalization of the data, and selecting from a set of candidate probes a sub-set of normalization probes that detect the second region.


Quanterix of Lexington, Mass., has received US Patent No. 8,222,047, "Ultra-sensitive detection of molecules on single molecule arrays." Methods are provided for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. They include immobilizing analyte molecules or particles to form complexes, releasing some of the complexes, determining what complexes are released, and measuring the concentration of the analyte molecules or particles in the fluid sample.


Samsung Electronics of Seoul, Korea, has received US Patent No. 8,222,391, "Oligonucleotide primer set for amplifying target sequence(s) of norovirus, oligonucleotide probe or probe set specifically hybridizing with target sequence(s) of norovirus, microarray immobilized with the probe or probe set, and method of detecting norovirus using the probe or probe set." The patent provides an oligonucleotide primer set for amplifying at least one target sequence of the genomic RNA of norovirus, an oligonucleotide probe or probe set that specifically hybridizes with at least one target sequence of the genomic RNA of norovirus, a microarray immobilized with the probe or probe set, and a method of detecting norovirus using the probe or probe set.


Affymetrix of Santa Clara, Calif., has received US Patent No. 8,224,586, "System, method, and computer product for exon array analysis." The claimed method includes receiving user selections of data files, and identifying subsets of intensity values acquired from biological probe arrays. More specifically, it includes iteratively opening each data file, identifying the selected subset of intensity values associated with each open data file, determining parameters for processing, storing the parameters and the identified intensity values, and closing the open data file prior to the subsequent iteration. The method then includes processing the stored intensity values using the parameters to identify one or more biological events.

The Scan

Breast Cancer Risk Related to Pathogenic BRCA1 Mutation May Be Modified by Repeats

Several variable number tandem repeats appear to impact breast cancer risk and age at diagnosis in almost 350 individuals carrying a risky Ashkenazi Jewish BRCA1 founder mutation.

Study Explores Animated Digital Message Approach to Communicate Genetic Test Results to Family Members

In the Journal of Genetic Counseling, the approach showed promise in participants presented with a hypothetical scenario related to a familial hereditary breast and ovarian cancer syndrome diagnosis.

Computational Tool Predicts Mammalian Messenger RNA Degradation Rates

A tool called Saluki, trained with mouse and human messenger RNA data, appears to improve mRNA half-life predictions by taking RNA and genetic features into account, a Genome Biology paper reports.

UK Pilot Study Suggests Digital Pathway May Expand BRCA Testing in Breast Cancer

A randomized pilot study in the Journal of Medical Genetics points to similar outcomes for breast cancer patients receiving germline BRCA testing through fully digital or partially digital testing pathways.