Affymetrix of Santa Clara, Calif., has received US Patent No. 8,273,304, "Analytical biochemistry system with robotically carried bioarray." The claimed system includes a substrate hosting reactants immobilized at fixed, known locations; a holder supporting the substrate; and a manipulator for transporting the holder to a fixed sample and to an inspection station. According to the patent, the reactants are binding agents for a target biomolecule in a sample, which forms a bound substance having a detectable characteristic, and the holder may be a standard pipettor, optionally carried by a robot arm or hand as the manipulator to contact the sample for detection of the presence of target biomolecules within the sample. Probing of the substrate is performed to identify binding or complexing of target biomolecules of the sample with the reactants immobilized on the substrate, and may be accomplished via fluorescence detection, light scattering, autoradiography, or some other detection method.
Scienion of Berlin has received US Patent No. 8,273,307, "Microdispenser and associated operating method." The device consists of a microdispenser for dispensing a liquid sample, a sample container for receiving the liquid sample, and a nozzle for dispensing the sample. The microdispenser can be stored independently of and fluidically separately from the dispensing device, without the sample escaping from the sample container during storage, according to the patent.
Bio-Layer of Queensland, Australia, has received US Patent No. 8,273,403, "Generation of surface coating diversity." The patent describes a surface discovery system and high-throughput combinatorial synthesis methods for generating large numbers of diverse surface coatings on solid substrates. The system is built upon a synthon that consists of three elements: a chemical backbone coating on the solid substrate that comprises a copolymer of a passive constituent and an active constituent; a spacer unit separating the backbone from a functional group; and a functional group.
Canon of Tokyo has received US Patent No. 8,273,529, "Method for hybridizing nucleic acids and hybridization apparatus." The patent claims a method for hybridizing a target nucleic acid and a probe nucleic acid that can specifically bind to the target nucleic acid and that is immobilized on a substrate. According to the patent, the method includes a first reaction step of allowing the target nucleic acid contained in a sample solution to react with the probe nucleic acid, a recovery step of recovering the sample solution after the first reaction step, a heating step of heating the recovered sample solution to the denaturation temperature of the target nucleic acid or a higher temperature, and a second reaction step of allowing the target nucleic acid contained in the sample solution after the heating step to react with the probe nucleic acid.
Samsung Electronics of Seoul, Korea, has receives US Patent No. 8,273,533, "Patterned spot microarray using photocatalyst and method of manufacturing the same." A method is claimed for preparing a patterned spot microarray using a photocatalyst. The method includes coating the photocatalyst on a substrate to form a photocatalyst layer, coating a composition consisting of a functional group to be connected to a biomolecule on the photocatalyst layer to form an organic layer, spotting the biomolecule on the organic layer, positioning a photomask above a spot of the biomolecule, and irradiating the spot through the photomask to pattern the spot.
The California Institute of Technology of Pasadena has received US Patent No. 8,273,574, "Apparatus and methods for conducting assays and high throughput screening." The patent describes microfluidic devices that include elastomeric components and consist of a main flow channel; a number of branch flow channels; a number of control channels; and a number of valves. According to the patent, each of the valves consists of one of the control channels and an elastomeric segment that is deflectable into or retractable from the main or branch flow channel upon which the valve operates in response to an actuation force applied to the control channel.