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IP Roundup: Affymetrix, ANP Technologies, Shaan Xi LifeGen, Biometrix Technology

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Affymetrix has received US Patent No. 8,501,122, "Manufacturing and processing polymer arrays." The patent provides methods for making and using plates that host sensors, such as high-density oligonucleotide microarrays. The methods include selecting a substrate containing sensors, aligning the substrate to the plate, and attaching it to the plate. Moduled sensor plates, capable of hosting strips of microarrays, are also provided. The plates can be inserted into processing plates, including hybridization, washing, staining, and detection plates, according to the patent.


ANP Technologies of Newark, Del., has received US Patent No. 8,501,399, "Asymmetrically branched polymer conjugates and microarray assays." The patent provides a means for detecting a target molecule. It is accomplished by exposing a sample containing the target molecule to a conjugate that consists of a modified randomly branched polymer without a core, and a bioactive reagent. The agent then binds to the target and is detected.


Shaan Xi LifeGen of Shaanxi, China, has received US Patent No. 8,501,459, "Test probes, common oligonucleotide chips, nucleic acid detection method, and their uses." The patent provides a high-throughput, chip-based detection for a base or mutation site of interest in a nucleic acid sample. It relies on linear test probe pairs P1 and P2, which comprise either of the flanking complementary sequences which are adjacent to the interesting base or the mutation site in the nucleic acid sample. Researchers can apply the method to resequence target nucleic acid sequences, and to detect the mutation, insertion, or deletion sites of a known nucleic acid sequence, as well as to genotype the pathogenic microorganism.


Biometrix Technology of Chuncheon, South Korea, has received US Patent No. 8,501,996, "Iminecalixarene derivatives and aminocalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA by using the self-assembled monolayer, and oligo-DNA chip prepared by the method." The patent provides a method for preparing an iminecalixarene and aminocalixarene compounds capable of fixing oligo-DNA molecules having consecutive guanine bases on the surface of a solid substrate by molecular recognition in a monolayer on a glass substrate or gold substrate. A method for preparing an oligo-DNA monolayer, such as an oligo-DNA chip, using the self-assembled monolayer is also claimed.

The Scan

Removal Inquiry

The Wall Street Journal reports that US lawmakers are seeking additional information about the request to remove SARS-CoV-2 sequence data from a database run by the National Institutes of Health.

Likely to End in Spring

Free lateral flow testing for SARS-CoV-2 may end in the UK by next spring, the head of Innova Medical Group says, according to the Financial Times.

Searching for More Codes

NPR reports that the US Department of Justice has accused an insurance and a data mining company of fraud.

Genome Biology Papers on GWAS Fine-Mapping Method, COVID-19 Susceptibility, Rheumatoid Arthritis

In Genome Biology this week: integrative fine-mapping approach, analysis of locus linked to COVID-19 susceptibility and severity, and more.