Agilent Technologies has received US Patent No. 7,750,908, "Focus plus context viewing and manipulation of large collections of graphs." The patent claims methods, systems and computer-readable media for visualizing a collection of graphs, where each of the graphs may be aligned along one axis of a visualization scheme. In one embodiment, the patent describes a computer-implemented method of displaying a large dataset of microarray comparative genomic hybridization data as a collection of graphs, with each graph composed of an ordered set of pairs of values. The patent also provides a means for selecting and sorting all graphs by similarity calculations between the data in each graph, as well as a means for displaying the metadata values and graphs in an order resulting from such sorting.
Agilent has also received US Patent No. 7,754,475, "Nucleic acid probes and microarrays for analysis of polynucleotides." The patent claims a probe set for detecting a target polynucleotide. It includes: a) a first oligonucleotide bound to a surface of a solid support by its 3' end that contains a surface-proximal target complementary region that base-pairs with the target polynucleotide to form a probe-target duplex, and a surface-distal stem-complementary region; and b) a second oligonucleotide that includes a loop region and a stem region, where the stem region is complementary to the stem-complementary region. According to the patent, hybridization of the first oligonucleotide and second oligonucleotide results in a stem-loop in which the 3' terminal nucleotide of the second oligonucleotide is directly adjacent to the 5' terminal nucleotide of the first oligonucleotide, where the stem-loop stabilizes the probe-target duplex.
Affymetrix has received US Patent No. 7,754,451, "Multiplex oligonucleotide addition and target amplification." The patent claims methods for appending oligonucleotides directly to nucleic acid templates, particularly to defined sites internal to single-stranded templates. By appending first and second common priming sites to each of a number of templates of distinct sequence, the subsequent stoichiometric amplification of a number of templates of distinct sequence is accomplished, the patent states.
Tufts University has received US Patent No. 7,754,498, "Self-encoding sensor with microspheres." The patent describes a microsphere-based analytic chemistry system in which self-encoding microspheres with distinct characteristic optical response signatures to specific target analytes may be mixed and identified using an encoding scheme. The system relies on an optical fiber bundle sensor in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios, according to the patent.
ANP Technologies of Newark, Del., has received US Patent No. 7,754,500, "Asymmetrically branched polymer conjugates and microarray assays." The patent describes asymmetrically-branched polymers that can be combined with bioactive agents for use in drug delivery and conjugation to one member of a binding pair for use in an assay. In one embodiment, non-modified or modified asymmetrically branched polymers can be used to carry protein molecules to various solid surfaces, and can be used for the generation of plate microarrays.