Sequenom has received US Patent No. 7,608,394, "Methods and compositions for phenotype identification based on nucleic acid methylation." The patent claims methods for identifying an unknown phenotype of a tissue that correlates with changes in the methylation state of the tissue. The methods include: a) contacting a nucleic acid sample from the tissue with a reagent that modifies unmethylated cytosine to produce uracil; b) amplifying the nucleic acid target gene region using at least one primer that hybridizes to a strand of the nucleic acid target gene region to produce amplified nucleic acids; c) determining the characteristic methylation state of the nucleic acid target gene region by base specific cleavage and identification of methylation sites; and d) comparing the ratio of methylated cytosine to unmethylated cytosine for each methylation site of the nucleic acid target gene region to the ratio of methylated cytosine to unmethylated cytosine for each methylation site of a tissue nucleic acid sample of the same type having a known phenotype, thereby identifying the unknown phenotype.
The California Institute of Technology of Pasadena has received US Patent No. 7,608,419, "Method and apparatus for detecting and quantifying bacterial spores on a surface." According to the method, a matrix including lanthanide ions is provided on the surface containing the bacterial spores; functionalized aromatic molecules are then released from the bacterial spores on the surface; a complex of the lanthanide ion and the aromatic molecule is subsequently formed on the surface; the complex of the lanthanide ion and the aromatic molecule is then excited to generate a characteristic luminescence of the complex on the surface; and the bacterial spores exhibiting the luminescence of the complex on the surface are detected and quantified.
Applied Precision of Issaquah, Wash., has received US Patent No. 7,608,840, "System and method employing photokinetic techniques in cell biology imaging applications." The methods include acquiring image data of an object by: a) selectively inducing photoactivation of material at a site on the object; b) performing an optical axis integration scan; c) executing a time delay integration scan sequence; and d) processing acquired image data in accordance with one or more desired analyses.
Agilent Technologies has received US Patent No. 7,608,841, "System and method for a fluorescence excitation and detection having distinct optical paths." The patent claims a system and method for fluorescence excitation and detection. The system for detecting fluorescence includes: a) a light source that emits an excitation light into an illumination tube; b) a number of collection optics located around an aperture in the illumination tube for collecting fluorescence; and c) a detector for determining the amount of fluorescence. The method for detecting fluorescence includes: a) emitting an excitation light from a light source into an illumination tube; b) directing the excitation light to an excitation filter; c) illuminating a sample with the excitation light to generate an emission light; and d) detecting the optical characteristics of the emission light using collection optics located around the illumination tube.