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IP Roundup, May 11, 2010


Columbia University has received US Patent No. 7,713,698, "Massive parallel method for decoding DNA and RNA." The patent provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The patent also provides nucleotide analogues that compose unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the -OH group at the 3'-position of the deoxyribose.

Riken of Wako, Japan, has received US Patent No. 7,713,706, "Method of fixing low-molecular compound to solid-phase support." The patent provides a method of fixing a low-molecular compound to a solid-phase support, by bringing a solution containing a low-molecular compound into contact with a solid-phase support that contains a photoreactive compound bonded to the surface. The solution that contains a low-molecular compound is then evaporated, and the solid-phase support is irradiated with light to form a covalent bond between the photoreactive compound and the low-molecular compound. This fixing method enables a low-molecular compound to be fixed to a solid-phase support without the aid of a functional group, according to the patent.

The Industrial Technology Research Institute of Hsinchu, Taiwan, has received US Patent No. 7,713,749, "Substrate for fabricating protein microarrays." The invention provides a substrate for protein microarrays, whereby a compound A and 3-glycidoxypropyltrimethyoxysilane are mixed for coating onto a solid support to form a layer, wherein compound A is selected from a group consisting of nitrocellulose, poly(styrene-co-maleic anhydride) and polyvinylidene fluoride. Moreover, the present invention also provides a protein microarray by depositing proteins on said layer of said substrate.

Life Technologies has received US Patent No. 7,715,004, "Signal noise reduction for imaging in biological analysis." The patent claims a method for characterizing contributions to signal noise associated with charge-coupled devices adapted for use in biological analysis. Dark current contribution, readout offset contribution, photo response non-uniformity, and spurious charge contribution can be determined by the described methods and used for signal correction by systems of the present teachings, the patent states.

Syngenta of Basel, Switzerland, has received US Patent No. 7,715,990, "Probe correction for gene expression level detection." The patent claims a method of correcting oligo probe hybridization signals by deriving a correction coefficient for an oligo probe using genomic DNA hybridizations to a microarray. This is accomplished by measuring signals from each oligo probe during multiple genomic DNA hybridizations to the array, where the multiple genomic DNA hybridizations are within a linear range. A correction coefficient is then calculated for each oligo probe based on the measured signals from the genomic DNA hybridizations according to a provided equation.

Petr Nikitin of Moscow has received US Patent No. 7,713,751, "Method of optical detection of binding of a material component to a sensor substance due to a biological, chemical or physical interaction and apparatus for its embodiment (variants)." The patent claims a method for detecting the binding of biological and chemical components of liquid or gaseous mixtures and solutions that are of mainly biological origin and determine parameters of living activity of biological objects, to substances that bind these components due to a biological, chemical or physical interaction, in order to determine the presence of biological and chemical components. According to the patent, binding substances are arranged on a surface of or inside a sensor layer that changes its thickness due to the binding being detected. The layer is affected by light of different wavelengths, and a signal due to interference on the sensor layer is registered in the reflected or transmitted light.

Johns Hopkins University has received US Patent No. 7,713,750, "Ablation based laser machining of biomolecule patterns on substrates." The patent claims a method for patterning biomolecules on a substrate that includes coating the substrate with a coating of the biomolecules, applying a laser to the coating, and ablating a portion of the biomolecules with the laser in a predetermined pattern.

The Scan

Missed Early Cases

A retrospective analysis of blood samples suggests early SARS-CoV-2 infections may have been missed in the US, the New York Times reports.

Limited Journal Editor Diversity

A survey finds low diversity among scientific and medical journal editors, according to The Scientist.

How Much of a Threat?

Science writes that need for a provision aimed at shoring up genomic data security within a new US bill is being questioned.

PNAS Papers on Historic Helicobacter Spread, Brain Development, C. difficile RNAs

In PNAS this week: Helicobacter genetic diversity gives insight into human migrations, gene expression patterns of brain development, and more.