Illumina has received US Patent No. 7,604,173, "Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same." The patent claims a method and apparatus for writing a code on an optical element. Specifically, the code is written on the optical element in the form of a holographic image of an n-dimensional code generated by an interference pattern between a reference beam and a signal beam reflected off a spatial light modulation device configured with the n-dimensional code. The method includes the steps of generating the interference pattern between the reference beam and the signal beam reflected off the spatial light modulation device having the n-dimensional code thereon, as well as writing the interference pattern on the optical element as a holographic image of the n-dimensional code.
Illumina has also received US Patent No. 7,604,996, "Compositions and methods for preparing oligonucleotide solutions." The patent describes a method for generating a pool of oligonucleotides that includes providing a substrate and different oligonucleotides linked to the substrate through cleavable linkers. The method also includes cleaving the linkers, releasing the oligonucleotides from the substrate, and generating a pool of oligonucleotides.
Life Technologies has received US Patent No. 7,604,937, "Encoding and decoding reactions for determining target polynucleotides." The patent claims methods, reagents, and kits for detecting the presence or absence of target polynucleotide sequences in a sample using encoding and decoding reactions. According to the patent inventors, when a particular target polynucleotide is present in a sample, a reaction product is formed in the encoding reaction that includes addressable primer portions. At least one label and at least one address primer is then employed in the decoding amplification reaction to provide a detectable signal value depending upon whether a sequence is present or absent.
Fluidigm of South San Francisco, Calif., has received US Patent No. 7,604,965, "Thermal reaction device and method for using the same." The patent claims a microfluidic device for performing a matrix of reactions. According to the inventors, the device includes a number of reaction cells that are in communication with either a sample inlet or a reagent inlet that is formed within an elastomeric block of the device. The patent also describes a method for forming such inlets in parallel in an elastomeric layer of an elastomeric block of a microfluidic device by using patterned photoresist masks and etching reagents to etch away regions or portions of an elastomeric layer of the elastomeric block.
Stanford University has received US Patent No. 7,604,983, "Apparatus and methods for parallel processing of micro-volume liquid reactions." Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.
Corning has received US Patent No. 7,604,984, "Spatially scanned optical reader system and method for using same." The patent claims an optical reader system that uses a scanned optical beam to interrogate a biosensor to determine if a biomolecular binding event occurred on a surface of the biosensor. The optical reader system includes a light source, a detector, and a processor. According to the inventors, the light source outputs an optical beam that is scanned across a moving biosensor while the detector collects the optical beam which is reflected from the biosensor. The computer processes the collected optical beam and records the resulting raw spectral or angle data that is a function of a position on the biosensor. The processor can then analyze the raw data to create a spatial map of resonant wavelength or resonant angle, which indicates whether a biomolecular-binding event occurred on the biosensor.
Boston Probes of Bedford, Mass., has received US Patent No. 7,605,253, "Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation." The patent claims a method for forming a terminal oligomer block and a condensing oligomer block from a bifunctional single set library. The method includes: a) providing a bifunctional single set library of at least two oligomer blocks; b) treating an oligomer block of the bifunctional single set library to remove one or more protecting groups and produce a terminal oligomer block; and c) treating an oligomer block of the bifunctional single set library to produce a condensing oligomer block.