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IP Roundup: Mar 23, 2010

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Covance of Princeton, NJ, has received US Patent No. 7,682,572, "Frozen tissue microarray." The patent describes a tissue microarray composed of frozen tissue cores that extend from the top of the tissue microarray to a release. According to the patent, the release is a material from which embedding material of the tissue microarray can easily be removed. A stiffener is used with the release to maintain its flat shape. By using the release, cores of frozen embedding material can be removed from the tissue microarray during the process of inserting donor tissue cores into the embedding material of the tissue microarray, the inventors state.


Affymetrix has received US Patent No. 7,682,782, "System, method, and product for multiple wavelength detection using single source excitation." The patent describes a method for adjusting the system gain of an array scanner for a number fluorophore species. The method includes setting an excitation beam at a first power level that elicits an optimal signal-to-noise ratio response from a first fluorophore species; scanning an array with the excitation beam; setting the excitation beam at a second power level different than the first power level; and scanning the array with the excitation beam.


Corning of Corning, NY, has received US Patent No. 7,682,802, "Assay solution compositions and methods for GPCR arrays." The patent claims buffered assay solutions for performing binding or functional assays on G protein-coupled receptor arrays. According to the patent, the buffered assay solution is composed of a buffer reagent; an inorganic salt of either a monovalent or divalent species; and an optional combination of a blocker reagent or a protease-inhibitor.


Stanford University has received US Patent No. 7,682,837, "Devices and methods to form a randomly ordered array of magnetic beads and uses thereof." The patent claims devices and methods for forming and using random arrays of magnetic particles. It provides a chip with magnetic domains that produce localized magnetic fields capable of immobilizing magnetic particles. Probe or sensor molecules can be coupled to the beads, which are then dispersed on the chip, forming a random-order array.


Stanford University has received US Patent No. 7,682,838, "Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules." The patent describes magnetic nanoparticles that can be attached to nucleic acid molecules. These molecules are then captured by a complementary sequence attached to a detector, such as a spin valve detector or a magnetic tunnel junction detector, according to the patent.

The Scan

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.

Study Highlights Pitfall of Large Gene Panels in Clinical Genomic Analysis

An analysis in Genetics in Medicine finds that as gene panels get larger, there is an increased chance of uncovering benign candidate variants.

Single-Cell Atlas of Drosophila Embryogenesis

A new paper in Science presents a single-cell atlas of fruit fly embryonic development over time.

Phage Cocktail Holds Promise for IBD

Researchers uncovered a combination phage therapy that targets Klebsiella pneumonia strains among individuals experiencing inflammatory bowel disease flare ups, as they report in Cell.