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IP Roundup: May 18, 2010


Syngenta of Basel, Switzerland, has received US Patent No. 7,715,990, "Probe correction for gene expression level detection." The patent claims a method of probe correction where individual probes on microarrays are rescaled and corrected with a set of probe-dependent coefficients derived from genomic-DNA hybridization signals. A dynamic range for gDNA binding is then determined by measuring a concentration signal curve. Signals for each probe are measured during multiple hybridizations within a linear range, and concentration insensitive probes are then found for two sets of experiments, the patent states. Probes are subsequently discarded based on a threshold compared to their standard deviation divided by their average in each set. Finally, a call for each gene is made, such as absent, marginal, or present.

CapitalBio and Tsinghua University both of Beijing have received US Patent No. 7,718,362, "DNA chip based genetic typing." The patent provides a method for typing a target gene using a chip, where the chip includes: a support suitable for use in nucleic-acid hybridization containing immobilized oligonucleotide probes complementary to the target nucleotide sequences, as well as oligonucleotide control probes. The control probes may include a positive control probe, a negative control probe, a hybridization control probe, and an immobilization control probe, according to the patent. Oligonucleotide probes or probes arrays for typing a human leukocyte antigen target gene are also provided.

Agilent Technologies has received US Patent No. 7,718,365, "Microarray analysis of RNA." The patent provides a method of performing an array analysis. The method includes contacting a sample of RNA with an analogous DNA set to provide a DNA/RNA duplex; contacting the DNA/RNA duplex with an enzyme having a DNA:RNA nuclease activity to provide a digested RNA sample; and contacting the digested RNA sample with an array under conditions sufficient to provide for specific binding to the array. The array typically is then interrogated. Kits are also described which include an analogous DNA set and an array.

Samsung Electronics has received US Patent No. 7,718,371, "Method and apparatus for isolating and purifying nucleic acid using a single surface." The patent claims a method of isolating nucleic acid from cells using a single surface, where a provided compound is bound to the surface. Also provided are an apparatus for isolation of nucleic acids, and a bead for isolating nucleic acids.

Samsung has also received US Patent No. 7,718,577, "Linker compound, substrate coated with the compound, method of producing microarray using the compound and microarray produced by the method." The patent claims a method of producing a microarray, by coating a provided compound on a solid substrate, and coupling the compound with a probe material to immobilize the probe material on the substrate.

Aviva Biosciences of San Diego has received US Patent No. 7,718,419, "Microdevices having a preferential axis of magnetization and uses thereof." The patent provides a microdevice that includes: a) a magnetizable substance; and b) a photorecognizable coding pattern, where the microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also claimed.

Mitsubishi has received US Patent No. 7,718,438, "Method for producing a microarray." The patent described a means of manufacturing a microarray by slicing a block of linear bodies or through-holes that carry an organism-related substance in a direction that intersects the longitudinal direction of the linear bodies or through-holes, where the block is composed of a substance that reduces self-fluorescence.

CombiMatrix has received US Patent No. 7,718,579, "Electrochemical deblocking using a hydrazine derivative." The patent claims a method for the electrochemical removal of acid-labile protecting groups on electrode microarrays using an organic solution. The described solution is composed of a hydrazine derivative and a salt in an organic solvent. The hydrazine derivative provides an acidic reagent when an electrode is active and isolates the acidic reagent to the area around the active electrode. The salt is an organic salt or ionic liquid that provides electrochemical conductivity under an applied voltage. During the applied voltage, the acidic reagent is generated, which removes acid-labile protecting groups and allows the continued addition of monomers to build a custom microarray of oligonucleotides, peptides, or other polymers.

The California Institute of Technology of Pasadena has received US Patent No. 7,720,614, "Method for identification of cis-regulatory modules via computational analysis of single polynucleotide polymorphisms (SNPs) and insertions/deletions (indels)." The patent describes a computational method that relies on the process of cis-regulatory module evolution to identify conserved sequence patches that exhibit suppression of change by SNP and indel occurrence. The method includes: a) determining sequence similarities significantly greater than random expectation on selected genome sequences from two or more species in sequences that lie outside of protein-coding regions; b) sorting the similarities for conserved patches of SNPs and indels; and c) selecting these patches to identify cis-regulatory modules.

The Scan

Mosquitos Genetically Modified to Prevent Malaria Spread

A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.

Gut Microbiomes Allow Bears to Grow to Similar Sizes Despite Differing Diets

Researchers in Scientific Reports find that the makeup of brown bears' gut microbiomes allows them to reach similar sizes even when feasting on different foods.

Finding Safe Harbor in the Human Genome

In Genome Biology, researchers present a new approach to identify genomic safe harbors where transgenes can be expressed without affecting host cell function.

New Data Point to Nuanced Relationship Between Major Depression, Bipolar Disorder

Lund University researchers in JAMA Psychiatry uncover overlapping genetic liabilities for major depression and bipolar disorder.