Grace Bio Labs of Bend, Ore., has received US Patent No. 8,034,306, "Reaction surface array diagnostic apparatus including a flexible microtitre plate." The device includes a substrate containing reaction surfaces as well as plate wells that can be aligned with one of the reaction surfaces to form a fluid-tight well. According to the patent, the plate is formed of a flexible material that may have an adhesive on one surface. Interlocking latches are also formed on the plate as is a frame for sealing the plate to the substrate.
The Wisconsin Alumni Research Foundation of Madison has received US Patent No. 8,034,550, "Chemical screening system using strip arrays." The patent claims a method of manufacturing strips of a non-reactive substrate extending along a longitudinal axis and supporting a linear array of different, chemically reactive substances exposed on a surface of the strip. According to the patent, the chemically reactive substances are spaced at different locations along the longitudinal axis to synthesize different kinds of chemicals.
Gen-Probe of San Diego has received US Patent No. 8,034,554, "Methods and compositions to detect nucleic acids in a biological sample." According to the patent, the target nucleic acid can be separated from a sample by using a capture probe oligonucleotide that contains a target-complementary region and a member of a specific binding pair that attaches the target nucleic acid to an immobilized probe on a capture support. A capture hybrid is then formed that is separated from other sample components before the target nucleic acid is released from the capture support and hybridized to a detection probe to form a detection hybrid that produces a detectable signal that indicates the presence of the target nucleic acid in the sample.
Johns Hopkins University of Baltimore, Md., has received US Patent No. 8,034,609, "Ablation based laser machining of biomolecule patterns on substrates." The claimed method includes coating the substrate with biomolecules; applying a focused laser onto the biomolecules; and ablating a portion of the biomolecules with the laser in a predetermined pattern. According to the patent, the predetermined pattern can consist of a number of ablated portions and non-ablated portions containing active or functional biomolecules.
Affymetrix has received US Patent No. 8,034,912, "Parallel preparation of high fidelity probes in an array format." The patent claims a method for massively parallel oligonucleotide probe synthesis and the release of the synthesized oligonucleotides from an array of probes on a solid substrate. The method includes providing a solid substrate; attaching linkers to the substrate, where each contains a cleavable moiety that can be activated only in certain conditions; and attaching monomers to the linkers until the desired array of synthesized oligonucleotides is complete. The array is then subjected to conditions to activate the cleavable moieties, ultimately allowing the release of the synthesized oligonucleotides from the array.
Agilent Technologies of Santa Clara, Calif., has received US Patent No. 8,036,835, "Probe design methods and microarrays for comparative genomic hybridization and location analysis." The patent describes a computer-implemented method for generating a set of probe nucleic acid sequences. The method includes sorting candidate probe nucleic acid sequences for a genomic region of interest, from smallest genomic distance to largest genomic distance between neighboring candidate probe nucleic acid sequences; evaluating a probe parameter for a neighboring pair of candidate probe nucleic acid sequences to identify a member of a pair with a more desirable parameter than another; removing the less desirable member; reiterating the sorting process; and outputting the set of probe nucleic acid sequences.