Samsung Electronics of Seoul, Korea, has received US Patent No. 7,985,453, "Apparatus for calibrating optical scanner, method of manufacturing the same, and method of calibrating optical scanner using the same." The claimed method includes contacting a substrate coated with a functional group and a molecule capable of forming an activated excimer to immobilize the molecule on the substrate. According to the patent, the functional group is an amino group derived from a compound selected from the group consisting of .gamma.-aminopropyltriethoxysilane, putrescine, spermidine, and spermine.
Northwestern University of Evanston, Ill., has received US Patent No. 7,985,539, "Nanoparticle probes with Raman spectroscopic fingerprints for analyte detection." New types of particle probes having a specific binding member bound to them are described. The reagents are used in a detection strategy that relies on the catalytic properties of gold nanoparticles to generate a silver coating that can behave as a surface-enhanced Raman scattering promoter for the dye-labeled particles that have been captured by target and an underlying chip in microarray format. According to the inventors, this approach provides the "high sensitivity and high selectivity" attributes of grey-scale scanometric detection but provides a route to multiplexing and rationing capabilities since a very large number of probes can be designed based upon the concept of using a Raman tag as a spectroscopic fingerprint in detection. These spectra are then used as fingerprints to differentiate oligonucleotide or other targets in one solution.
Affymetrix has received US Patent No. 7,985,547, "Capturing sequences adjacent to type-IIs restriction sites for genomic library mapping." Methods for sequencing and mapping genetic markers in polynucleotide sequences using Type-IIs restriction endonucleases are provided. The methods result in the capturing and determination of specific oligonucleotide sequences located adjacent to Type-IIs restriction sites. The inventors claim the resulting sequences are useful as markers for use in genetic mapping, screening, and manipulation.
Institut National de la Sante et de la Recherche Medicale of Paris has received US Patent No. 7,985,549, "Method for predicting responsiveness to TNF-alpha blocking agents." An in vitro method for predicting whether a patient will respond to a treatment with a TNF-alpha-blocking agent is claimed. The method includes determining the expression level of eight genes in a biological sample of a patient, where the genes are EPS15, HLA-DPB1, AKAP9, RASGRP3, MTCBP-1, PTNP12, MRPL22 and RPS28. A DNA chip for performing the method is also included.
Illumina of San Diego has received US Patent No. 7,985,565, "Method of nucleic acid amplification." According to the patent, the method includes the annealing of a nucleic acid molecule to an appropriate immobilized primer. The primer can then be extended and the molecule and the primer can be separated from one another. The extended primer can then be annealed to another immobilized primer and the other primer can be extended. Both extended primers can then be separated from one another and can be used to provide further extended primers. The process can be repeated to provide amplified, immobilized nucleic acid molecules.
Panasonic of Osaka, Japan, has received US Patent No. 7,985,598, "Biomolecule-immobilized plate and method for fabricating biomolecule-immobilized plate." A biomolecule-immobilized plate containing a flat part is provided, where the surface of the flat part of the plate consists of a polymer material. The described plate is fabricated by irradiating it with an ultraviolet ray under ozone atmosphere to produce functional groups having bonding ability to the biomolecules on its surface.
Receptors of Chaska, Minn., has received US Patent No. 7,985,715, "Combinatorial artificial receptors including peptide building blocks." Artificial receptors, arrays, or microarrays of artificial receptors or candidate artificial receptors as well as methods for making and using them are described. Each artificial receptor includes a building block molecule that is a peptide of a claimed formula.
The University of Chicago has received US Patent No. 7,985,716, "Nucleic acid sample purification and enrichment with a thermo-affinity microfluidic sub-circuit." An integrated thermo-affinity sample preparation sub-circuit for sample purification and enrichment is described that is consistent with a field-portable form factor and analytical processes. According to the inventors, multiplexed affinity purification and thermal dissociation prior to biochip hybridization simplifies uncharacterized sample admixtures, minimizes sample interferents, improves hybridization specificity on a microarray detector, and minimizes the need for post-hybridization thermal dissociation analysis.
The University of Colorado of Denver has received US Patent No. 7,987,056, "Mixed-library parallel gene mapping quantitative microarray technique for genome-wide identification of trait conferring genes." Methods relating to mixed-library parallel gene trait mapping are claimed. The methods concern quantitative microarray hybridization techniques for genome-wide identification of trait conferring genes. Genetic elements that confer or are associated with enhanced bacterial growth rate are also claimed.