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IP Roundup: Dec 8, 2009

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Accelr8 Technology of Denver has received US Patent No. 7,629,029, "Functional surface coating." The patent claims methods of preparing functional thin films or surface coatings with low non-specific binding. According to the patent, the thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin-film-modified solid surfaces, and non-specific binding repellant components reduce the non-specific binding to the thin-film-modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films.


Honeywell International of Morristown, NJ, has received US Patent No. 7,629,115, "Cell-based platform for high throughput screening." The patent describes an apparatus for testing multiple sample compounds for their biological effect. The apparatus includes a porous block with planar top and bottom surfaces. The top surface has cell adhesive regions and cell dis-adhesive regions and the bottom surface provides multiple sites to load the sample compounds. These sites are located opposite from the cell adhesive regions on the top surface of the porous block.


Affymetrix has received US Patent No. 7,629,164, "Methods for genotyping polymorphisms in humans." The patent provides nucleic acid sequences that are complementary to a collection of human single nucleotide polymorphisms. The method provides the sequences in such a way as to make them available for a variety of analyses including genotyping a large number of SNPs in parallel by, for example, allele-specific hybridization. The patent also provides a collection of human SNPs that is useful for genetic analysis within and across populations.



Corning
of Corning, NY, has received US Patent No. 7,629,173, "Optical reader system and method for monitoring and correcting lateral and angular misalignments of label independent biosensors." The patent claims an optical reader system and method that can detect a lateral and/or angular misalignment of one or more biosensors so that the biosensors can be properly re-located after being removed from and then reinserted into the optical reader system. In one embodiment, the biosensors are incorporated within the wells of a microplate.

The Kitasato Institute and the National Institute of Technology and Evaluation of Japan have received US Patent No. 7,630,836, "Polynucleotides." The patent claims polynucleotides derived from microorganisms belonging to actinomycetes, polypeptides encoded by the polynucleotides, polynucleotide arrays composed of the polynucleotides, and recording media in which the nucleotide sequences of the polynucleotide are readable in a computer.

The Scan

Wolf Howl Responses Offer Look at Vocal Behavior-Related Selection in Dogs

In dozens of domestic dogs listening to wolf vocalizations, researchers in Communication Biology see responses varying with age, sex, reproductive status, and a breed's evolutionary distance from wolves.

Facial Imaging-Based Genetic Diagnoses Appears to Get Boost With Three-Dimensional Approach

With data for more than 1,900 individuals affected by a range of genetic conditions, researchers compared facial phenotype-based diagnoses informed by 2D or 3D images in the European Journal of Human Genetics.

Survey Suggests Multigene Cancer Panel VUS Reporting May Vary Across Genetic Counselors

Investigators surveyed dozens of genetic counselors working in clinical or laboratory settings, uncovering attitudes around VUS reporting after multigene cancer panel testing in the Journal of Genetic Counseling.

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.