NEW YORK (GenomeWeb) – Variants within the human leukocyte antigen (HLA) locus are likely the most important for predicting whether a kidney transplant will be successful, a new study has found.

While kidney transplant outcomes have improved over the past decade, there are a number of factors that affect long-term outcomes, including HLA mismatch. The HLA gene complex helps the immune system tell friend from foe, and close matches are needed in organ transplants to limit rejection.

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In Genome Research this week, mismatch repair deficiency in C. elegans, retracing transcriptions start site evolution in the human genome, and more. 

May
01
Sponsored by
Horizon Discovery

This webinar will provide an in-depth case study demonstrating how reference standards can be used to develop and validate circulating tumor DNA (ctDNA)-based assays.

May
08
Sponsored by
Dovetail Genomics

This webinar will discuss a proximity ligation-based method for studying structural variation in formalin-fixed paraffin-embedded (FFPE) tissue.