NEW YORK (GenomeWeb) – A genome-wide association study involving tens of thousand of children and adults has identified genetic variants associated with head size across the lifespan, including low-frequency variants in TP53 and other cancer-related genes.

"Our findings show that genome-wide approaches combining genetically and developmentally related phenotypes may enhance the power to identify even relatively rare genetic variation with large effect," co-first author Simon Haworth, a researcher in the University of Bristol MRC Integrative Epidemiology Unit, said in a statement.

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