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Funding Update: NSF Microarray Grants 2013


NSF Microarray Grants Awarded Jan 1 — June 25, 2013

Handheld multiplex immunoassay microfluidic device for water-based toxin detection
Start Date: Jan. 1, 2013
Expires: Dec. 31, 2013
Awarded amount to date: $149,180
Principal investigator: Hong Jiao
Sponsor: HJ Science & Technology

The investigators are developing an enzyme-linked immunosorbent assay that is run in a microfluidic device, and can be used in the environmental monitoring of harmful algal bloom toxins.

Personalized point-of-care immunity assessment platform
Start Date: Jan. 1, 2013
Expires: June 30, 2013
Awarded amount to date: Not available.
Principal investigator: Michael Harvey
Sponsor: Maine Manufacturing

The researchers intend to create a plasma-generating multiplexed epitope-specific test device for testing immunity to viral diseases, based on peptide array and epitope mapping technology.

New fluorescent biosensors for signaling in living cells
Start Date: Jan. 1, 2013
Expires: Dec. 31, 2013
Awarded amount to date: $164,423
Principal investigator: Anne Quinn
Sponsor: Montana Molecular

The investigators will explore the feasibility of developing a genetically-encoded biosensor to monitor levels of cyclic adenosine monophosphate, a second messenger component of drug signaling pathways.

Multifunctional nanobiointerfaces for sensing applications
Start Date: Feb. 1, 2013
Expires: Jan. 31, 2015
Awarded amount to date: $299,955
Principal investigator: Aleksandr Simonian
Sponsor: Auburn University

The investigators intend to develop a new device capable of multianalyte detection based on cascading layers on a single electrode. They see this approach as an alternative to multi-electrode arrays that rely on "complicated microfluidics" and "heavy computing."

Multichannel disposable sensors for animal health disease diagnostics
Start Date: May 15, 2013
Expires: April 30, 2016
Awarded amount to date: $358,393
Principal investigator: Eric Vogol
Sponsor: Georgia Tech Research

The investigators will develop a low-cost multiplexed electrochemical platform capable of detecting several antibody markers related to bovine respiratory disease infections.

Crosstalk-free multiplexed immunoassay of plasma biomarkers
Start Date: July 1, 2013
Expires: Dec. 31, 2015
Awarded amount to date: $149,715
Principal investigator: Arlyne Simon
Sponsor: PhasiQ

The investigators plan to develop and commercialize a test that monitors and quantifies levels of multiple proteins in biological fluids, targeting biomarkers that indicate disease onset, disease progression, or drug efficacy.

Polymer electrosonic actuation microarray: Low-cost tool for transfection of biological cells
Start Date: July 1, 2013
Expires: June 30, 2014
Awarded amount to date: $225,000
Principal investigator: John Meacham
Sponsor: OpenCell Technologies

The investigators intend to design and optimize a polymer microarray and to develop a low-cost system capable of generating the mechanical stress field needed to achieve improved treatment outcomes in difficult-to-transfect cells.

Microwell array plates for dual-mode screening of bead libraries
Start Date: July 1, 2013
Expires: Dec. 31, 2013
Awarded amount to date: $150,000
Principal investigator: Vladislav Bergo
Sponsor: Adeptrix

According to investigators, this project, if successful, will yield microchips with dual optical and mass spectrometry readouts that will enable the development of new methods of high-throughput screening and support the use of mass spectrometry in various HTS-based applications.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.