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Metabolite Trail

People leave a trail of metabolites behind them and researchers are increasingly able to identify them, the Economist writes, adding that these metabolites could be used to uncover personal information about people.

It notes that only recently have researchers been able to sample metabolites from more sources than blood or urine — they can now analyze sweat, saliva, and dental plaque — and databases for identifying metabolites based on their GC/MS profiles have improved. Such data, the Economist says, could reveal a lot about people: how much they exercise, what they eat, or if they take any drugs or medications.

While there are protections in the US barring employers or health insurers from using genetic information, the Economist notes there are no such protections for metabolic data and, further, that others like law enforcement could be interested in what such tests might reveal. 

"The day is coming soon," the University of Oklahoma's Cecil Lewis tells it, "when it will be possible to swab a person's desk, steering wheel, or phone and determine a wide range of incredibly private things about them."

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.