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Vincent Fusaro: Transforming Translational Medicine


Recommended by: Mark Boguski, Harvard Medical School

Vincent Fusaro is attempting to advance translational medicine using computational methods. This year, he received a K99/R00 Pathways to Independence grant from the National Library of Medicine to pursue this line of research and identify new uses for current drugs and then confirm their benefit using electronic medical records from health-care providers.

Also this year, Fusaro reported the results of a clinical trial simulation framework to model warfarin dosing and the International Normalization Ratio at the National Library of Medicine Informatics Training Conference.

For Fusaro, the Holy Grail of data would be full genomic data linked with full phenotype data across all individuals. "In collaboration with the Harvard hospitals, we've launched new initiatives to collect this information with proper patient consent," he says. "This would allow us to correlate genomic information with patient outcomes and help us understand which mutations are important for clinical treatment and which are part of the incidentalome."

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The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.