Post-Neoadjuvant Profiling Approach IDs Breast Cancer Chemo Resistance Mechanism, Suggests Potential Drug Target | GenomeWeb

Researchers from Vanderbilt University have profiled the gene expression of tumors that linger after neoadjuvant chemotherapy, finding that the transcript DUSP4 is highly associated with post-treatment proliferation and shorter recurrence-free survival.

DUSP4, while not directly actionable, is associated with pathway activity that could potentially be targeted with MEK inhibitors, the group reported in a paper in Nature Medicine last week.

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In PLOS this week: nasal microbial communities in asthma patients; sequencing-based way to detect, track schistosomiasis; and more.

The New York Times speaks with Vanderbilt's John Anthony Capra about Neanderthal genes in modern humans.

A draft guidance from the FDA suggests the agency wants to more tightly control gene-edited animals, according to Technology Review.

Researchers were among this weekend's protesters bemoaning the new US administration, Vox reports.