Post-Neoadjuvant Profiling Approach IDs Breast Cancer Chemo Resistance Mechanism, Suggests Potential Drug Target | GenomeWeb

Researchers from Vanderbilt University have profiled the gene expression of tumors that linger after neoadjuvant chemotherapy, finding that the transcript DUSP4 is highly associated with post-treatment proliferation and shorter recurrence-free survival.

DUSP4, while not directly actionable, is associated with pathway activity that could potentially be targeted with MEK inhibitors, the group reported in a paper in Nature Medicine last week.

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