Post-Neoadjuvant Profiling Approach IDs Breast Cancer Chemo Resistance Mechanism, Suggests Potential Drug Target | GenomeWeb

Researchers from Vanderbilt University have profiled the gene expression of tumors that linger after neoadjuvant chemotherapy, finding that the transcript DUSP4 is highly associated with post-treatment proliferation and shorter recurrence-free survival.

DUSP4, while not directly actionable, is associated with pathway activity that could potentially be targeted with MEK inhibitors, the group reported in a paper in Nature Medicine last week.

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In Science this week: genetic target for urothelial bladder cancer treatment, and more.

At the Conversation, the University of Oxford's Michael Macklay writes that learning genetic risk of disease is a personal decision.

Two dozen scientific organizations have endorsed the March for Science, according to ScienceInsider.

Researchers in Japan describe a chimpanzee with a chromosomal abnormality similar to human Down syndrome, Mashable reports.