Researchers at Cold Spring Harbor Laboratory have identified mutations that may lead to improved therapy for patients with mast cell leukemia, a form of acute myeloid leukemia that has a poor prognosis. Their research, published online in Leukemia in December, used exome sequencing and array comparative genomic hybridization to identify two previously unknown mutations in the genome of a patient with MCL. They found mutation in the genes KIT and MS4A2 that could predict response to currently available drugs.

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