A group of research centers spanning five continents is in the middle of a clinical trial intended to identify genetic and other markers that can predict response to three antidepressants.

According to Subhdeep Virk, a psychiatrist and principal investigator of the study at Ohio State’s Wexner Medical Center, the International Study to Predict Optimized Treatment of Depression, or iSPOT-D, is the largest biomarker discovery effort to identify predictors for depression treatment response.

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