A group of research centers spanning five continents is in the middle of a clinical trial intended to identify genetic and other markers that can predict response to three antidepressants.

According to Subhdeep Virk, a psychiatrist and principal investigator of the study at Ohio State’s Wexner Medical Center, the International Study to Predict Optimized Treatment of Depression, or iSPOT-D, is the largest biomarker discovery effort to identify predictors for depression treatment response.

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In Science this week: swapping yeast genes with human orthologs to study conservation of function, and more.

Hong Kong is using DNA phenotyping to shame litterers.

A study appearing in Cell suggests some metastatic castration-resistant prostate cancer patients could benefit from PARP inhibitor therapy.

NIH's Francis Collins writes that scientific advances are poised to help populations all over the world, but more scientists are needed to keep the momentum.