NEW YORK (GenomeWeb News) – A team at the Medical College of Wisconsin will use a five-year, $8.7 million grant from the National Heart, Lung, and Blood Institute to create new genetically modified rat models for studying genetics of human diseases, MCW said today.

Principal investigator Howard Jacob, director of MCW's Human and Molecular Genetics Center, will lead the effort using transcription activator-like effector nuclease gene editing technology to develop 200 gene-targeted knockout rat models and to disseminate them throughout the disease research community.

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In PNAS this week: genomic study of group B Streptococcus evolution, selection on the X chromosome in great apes, and more.

Changing the fat and fiber content of people's diets affects their gut microbiome, metabolome, and colon cancer risk, researchers say.

Broken links are found throughout academic publications, and some services are trying to combat such link decay.

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