NEW YORK (GenomeWeb) – While toll-like receptors (TLRs) are widely known as key players in the immune system, recognizing pathogens and triggering the release of inflammatory cytokines, much of the research in this field has focused on the activity of individual signaling proteins.

Aiming to take a systems-level approach to uncovering the protein-protein interactions that comprise TLR signaling, University of Texas at Arlington researcher Saiful Chowdhury has recently kicked off a project to develop mass spectrometry approaches for studying the host-defense interactome.

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A research duo estimates in PLOS One the number of papers that have used misidentified cell lines.

UK's National Institute for Health and Care Excellence approves GlaxoSmithKline's SCID gene therapy despite cost.

Science reports that Brazilian researchers are petitioning for the reversal of budget cuts.

In PLOS this week: gene flow patterns in common ash, guidelines for using morpholinos in zebrafish, and more.