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Lots and Lots of Triglycerides

Three siblings from a Pennsylvania Dutch family have a rare genetic condition that leads triglycerides to build up in their blood to the extent that it looks "milky," LiveScience reports.

It adds that the siblings, who are in their 50s, had been diagnosed with hypertriglyceridemia, but genetic testing has found that actually have a very rare condition called familial chylomicronemia syndrome. In a case report appearing in the Annals of Internal Medicine, researchers from the University of Pennsylvania report that the siblings inherited two copies of a novel mutation in the LPL gene. The siblings' parents were first cousins.

This, LiveScience notes, led the siblings' triglyceride levels to be very high: at their highest, they had triglyceride levels of 5,000 mg/dL, 6,000 mg/dL, and 7,200 mg/dL, respectively, while 500 mg/dL is typically considered high. But it adds that their condition appears to be responding to a fat-restricted diet.

The Scan

Foxtail Millet Pangenome, Graph-Based Reference Genome

Researchers in Nature Genetics described their generation of a foxtail millet pangenome, which they say can help in crop trait improvement.

Protein Length Distribution Consistent Across Species

An analysis in Genome Biology compares the lengths of proteins across more than 2,300 species, finding similar distributions.

Novel Genetic Loci Linked to Insulin Resistance in New Study

A team reports in Nature Genetics that it used glucose challenge test data to home in on candidate genes involved in in GLUT4 expression or trafficking.

RNA Editing in Octopuses Seems to Help Acclimation to Shifts in Water Temperature

A paper in Cell reports that octopuses use RNA editing to help them adjust to different water temperatures.