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IP Update: Recent Patents Related to PCR, Nucleic Acid Amplification, and Sample Prep: Jul 6, 2010

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Bio-Rad Laboratories has been awarded US Patent No. 7,749,736, "Systems and methods for fluorescence detection with a movable detection module."

Igor Kordunsky, Jeffrey Goldman, and Michael Finney are listed as inventors on the patent.

According to its abstract, the patent covers a fluorescence detection apparatus for analyzing samples located in a plurality of wells in a thermal cycler, as well as methods of use. In one embodiment, the apparatus includes a support structure attachable to the thermal cycler and a detection module movably mountable on the support structure. The detection module includes one or more channels, each having an excitation light generator and an emission light detector both disposed within the detection module. When the support structure is attached to the thermal cycler and the detection module is mounted on the support structure, the detection module is movable so as to be positioned in optical communication with different wells. The detection module is removable from the support structure to allow easy replacement, the abstract states.


Sungkyunkwan University in Korea has been awarded US Patent No. 7,749,732, "Method for preparing active Nanoarchaeum equitans DNA polymerase and the active DNA polymerase prepared by the method."

Suk-Tae Kwon, Jeong Jin Choi, and Ki Hoon Nam are listed as inventors on the patent.

The patent discloses a method of preparing an active Nanoarchaeum equitans B-type DNA polymerase, or Neq DNA polymeras; an active Neq DNA polymerase prepared according to the method; and a polymerase chain reaction using the active Neq DNA polymerase. The active Neq DNA polymerase may be used in various nucleic acid polymerization reactions, such as PCR, according to the patent's abstract.


Transgenomic has been awarded US Patent No. 7,749,708, "Method for identifying the sequence of one or more variant nucleotides in a nucleic acid molecule."

Paul Taylor, Gary Gerard, and Reyes Candau are listed as inventors on the patent.

Relates to methods for identifying the sequence of one or more variant nucleotides in a nucleic acid molecule. The method involves cleaving a double-stranded nucleic acid molecule containing a mismatch with a mismatch-specific endonuclease, which cleaves on the 3' side of the mismatch; and preserving the integrity of the variant nucleotide by ligating a double-stranded linker with a 3'-overhang to the variant nucleotide. Because the variant nucleotide is immediately adjacent to the linker, PCR and/or sequence-by-synthesis analysis can be readily carried out, according to the patent's abstract.


Symphogen in Lyngby, Denmark, has been awarded US Patent No. 7,749,697, "Method for linking sequences of interest."

Martin Oleksiewicz, Lars Nielsen, Peter Andersen, and Margit Hansen are named as inventors on the patent.

The patent covers a method called multiplex overlap-extension RT-PCR to link two or more nucleotide sequences encoding for domains or subunits of a heteromeric protein in a single reaction. The method especially eases the linkage of variable regions encoding sequences from, for example, immunoglobulins, T cell receptors, or B cell receptors according to the patent's abstract. This allows for a more efficient way of generating libraries of variable-region-encoding sequences. The capability to perform multiplex overlap-extension RT-PCR using template derived from an isolated single cell enables the generation of cognate pair libraries in a high-throughput format.

The Scan

Renewed Gain-of-Function Worries

The New York Times writes that the pandemic is renewing concerns about gain-of-function research.

Who's Getting the Patents?

A trio of researchers has analyzed gender trends in biomedical patents issued between 1976 and 2010 in the US, New Scientist reports.

Other Uses

CBS Sunday Morning looks at how mRNA vaccine technology could be applied beyond SARS-CoV-2.

PLOS Papers Present Analysis of Cervicovaginal Microbiome, Glycosylation in Model Archaea, More

In PLOS this week: functional potential of the cervicovaginal microbiome, glycosylation patterns in model archaea, and more.