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WorksBase, Garlic, pDraw32 1.1.28

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Bio-Rad of Hercules, Calif., has released WorksBase software, a bioinformatics platform for proteomics information management. The package provides a centralized data warehouse that integrates data generated from Bio-Rad’s ProteomeWorks hardware and software with external reference database information.

WorksBase also includes the capability to integrate proteomics data with others sources of information, including genomic, chromatographic, array, metabolic, biochemical, and molecular modeling data.

Bio-Rad has also launched version 6.2 of its PDQuest 2D analysis software. The new release offers enhanced annotation image viewing capabilities, as well as the ability to combine multiple pH range 2D gels.

Davor Juretic’s work group at the University of Split, Croatia, has released version 1.1 of its Garlic open source molecular visualization program.

Available at http://pref.etfos.hr/garlic, the latest version is able to draw six more structures than version 1.0, including a helical wheel for a given sequence segment and an averaged hydrophobicity and hydrophobic moment for a given sequence.

pDraw32 1.1.28, freeware DNA analysis software, is now available from AcaClone Software at www.geocities.com/acaclone.

New features of the current revision include analysis of GC-distibution and optional plotting of results, oligonucleotide database management, and oligonucleotide primer site analysis.

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The Scan

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.

Rett Syndrome Mouse Model Study Points to RNA Editing Possibilities

Investigators targeted MECP2 in mutant mouse models of Rett syndrome, showing in PNAS that they could restore its expression and dial down symptoms.

Investigators Find Shared, Distinct Genetic Contributors to Childhood Hodgkin Lymphoma

An association study in JAMA Network Open uncovers risk variants within and beyond the human leukocyte antigen locus.

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.