A couple of biologists walk into your office, explaining that they have a pile of data from their big experiment and would like some help with the analysis. They know just what they're looking for, but aren't sure how to get there. How do you choose the right tools for the job? This is probably a common question for many of us, whether we work at the bench or in front of a computer. Unless we're doing something that's novel or extremely specific, we probably have several options for algorithms or software. But which should we select?