Skip to main content
Premium Trial:

Request an Annual Quote

Web-Based Microarray Annotation Database Fills Genomics Research Gap, Developer Says


Page hits for Jonathan Pevsner’s web-based Dragon database doubled the day after a paper on the project appeared in the journal Bioinformatics, a response that Pevsner said indicates an overwhelming need for such a tool in genomics research.

Dragon (Database Referencing of Array Genes Online) was developed to help annotate and interpret microarray experiments. It extracts information relevant to the analysis of differential gene expression data from publicly available databases, such as Swiss-Prot, Pfam, Unigene, and KEGG, and compiles it in a single location.

Users can submit a list of Genbank accession numbers and expression values for thousands of genes from a microarray experiment using the Annotate page on the Dragon website. They can then indicate particular characteristics and Dragon annotates the list simultaneously.

Another feature, Dragon View, acts as a companion to the annotation feature. A suite of visualization tools represents whether families of related genes are all regulated in a similar manner or whether genes in the same cellular pathway are all differentially regulated.

Pevsner, principal investigator in the department of neurology at the Kennedy Krieger Institute in Baltimore, Md., and graduate student Chris Bouton implemented the database with Perl scripts with MySQL as the backend database. It runs on a RedHat 6.2 based Dell Poweredge 6300 server that Merck Pharmaceuticals donated in a “no strings” arrangement, according to Pevsner.

Dragon is freely available online (


Filed under

The Scan

Push Toward Approval

The Wall Street Journal reports the US Food and Drug Administration is under pressure to grant full approval to SARS-CoV-2 vaccines.

Deer Exposure

About 40 percent of deer in a handful of US states carry antibodies to SARS-CoV-2, according to Nature News.

Millions But Not Enough

NPR reports the US is set to send 110 million SARS-CoV-2 vaccine doses abroad, but that billions are needed.

PNAS Papers on CRISPR-Edited Cancer Models, Multiple Sclerosis Neuroinflammation, Parasitic Wasps

In PNAS this week: gene-editing approach for developing cancer models, role of extracellular proteins in multiple sclerosis, and more.