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University of Texas Scientists Speed Gene Function Determination

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DALLAS, Texas--A computer program recently developed at University of Texas Southwestern Medical Center at Dallas has found the markers on all DNA sequenced so far in the Human Genome Project. The list is now available on the internet at http://POMPOUS. swmed.edu/.

A UT Southwestern study that developed and validated the computer code known as POMPOUS (polymorphic marker prediction of ubiquitous simple sequen ces) is described in a recent issue of Proceedings of the National Academy of Sciences.

The researchers applied POMPOUS to a 750,000 base pair region on human chromosome 3P. This section of DNA was then used to study small-cell lung carcinoma. About 40 markers were identified and tested, accelerating research ers' ability to analyze and iden tify the genes and the properties of the sequence region.

Using a parallel supercomputer on loan from Hewlett-Packard, UT researchers have precalculated the markers in all genes that have been sequenced thus far. A list of 13,000-14,0000 markers is contained on the web site. The site also allows users to submit sequences and to utilize the code to predict the marker and retrieve oligonucleotide sequences.

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