Most proteomics researchers have resigned themselves to accepting 2D-gel electrophoresis as a necessary and low-throughput evil — the painstaking process remains the most popular way to separate complex protein mixtures, despite numerous attempts to improve upon it, or even replace it. Although several software packages are available to automate the comparison of 2D gel profiles, “most of them require a significant amount of user interaction,” said Guang-Zhong Yang, director of the Medical Image Computing Laboratory at Imperial College, London.

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The London School of Economics' Daniele Fanelli argues at the Proceedings of the National Academy of Sciences that the reproducibility crisis in science isn't as dire as some say.

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