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Sybyl for Mac OS X, MacVector 10, Connectivity Map

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Tripos International has announced a beta test program for its Sybyl software on the Mac OS X operating system. The test is designed to validate the comprehensive porting of the Sybyl molecular modeling environment to the Mac platform. The test program is now underway, and will continue through Aug. 15, with a full release planned for September.
 
The beta test program will allow participants access to all Sybyl base tools and modules for the testing period. Beta users need an Intel-based Mac, Mac OS X 10.5 Leopard, and an Nvidia graphics card.
 

 
MacVector of Cary, NC, has released MacVector 10, the second release of its sequence analysis application for Macintosh computers.
 
MacVector 10 has had an interface overhaul and offers a tabbed view to see sequences and a dynamic automatic restriction enzyme display to simplify clone construction.
 
A new feature editor to simplify the creation of GenBank style annotations has been added, along with a redesign of the Entrez browser with support for more databases and retrieval of genomic contig sequences.
 
Primer design has also been updated, with a new Primer3-based primer design function with support for real-time PCR primers and the design of primers. A new version of Assembler has also been released with real-time translation of contigs.
 
MacVector 10.0 can be downloaded here
 

 
The Broad Institute has released build 02 of the Connectivity Map, a collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules.
 
The new version of the resource includes more than 7,000 new genome-wide profiles of gene expression, which is 13 times the number of profiles available in the first version of the map released in 2006, the Broad said.
 
Build 02 now includes information on around 1,300 drugs or drug-like compounds, representing an eight-fold increase over the earlier version.

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