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SYBYL 7.1, Benchware Notebook 2.0, Benchware Dock, KnowItAll Informatics System, REDI (Reduction of Invariant Probes), Sreeni Devidas, Tidu Maini, John O Connell, Atul Butte


Downloads & Upgrades

Tripos has released SYBYL 7.1. The new version of the molecular modeling environment includes a new application for ligand-based drug design called GALAHAD (Genetic Algorithm with Linear Assignment for Hypermolecule Alignment of Datasets). Developed in collaboration with Biovitrum, GALAHAD creates pharmacophore and alignment models from sets of flexible, active compounds. SYBYL 7.1 also includes new versions of former Optive Research products — ProtoPlex, Concord, DiverseSolutions, StereoPlex, and CombiLibMaker — and improvements to the speed and quality of UNITY searches.

Tripos also released two products in its Benchware line of laboratory informatics software: Benchware Notebook 2.0, an enterprise electronic laboratory notebook, and Benchware Dock 1.0, a real-time virtual-screening program.

Bio-Rad Laboratories last week released version 6.0 of its KnowItAll Informatics System. The release includes the KnowItAll Enterprise Server, which enables customers to centralize analytical, biological, and chemical data on a secure server; a new command line interface feature; a new KnowItAll MedChem Edition that is designed for medicinal chemists; and a new OptimizeIt application that suggests modifications of lead compounds for medicinal chemists. The release also includes new experimental ADME/tox databases and a feature that allows confidence levels to be displayed for in silico ADME/tox predictions.

Gene-IT has launched a new "sequence-centric" data integration service. According to the company, the approach allows end users to use sequence data identifiers "to select, sort, and filter previously undiscovered sequence records" in real time "without the need for database technology."

Expression Analysis said that it has added a new analytical method to its service offering for analyzing Affymetrix GeneChip data. The approach, called REDI (Reduction of Invariant Probes) analysis, masks the affect caused by potentially invariant probes within a probe set in order to provide a more accurate indication of potential differential expression, the company said. The company said that REDI can be used with any current signal measures, such as RMA, PDNN, dChip, MAS5, or PLIER.


People in the News

Sreeni Devidas has joined Ingenuity Systems as vice president of business development. Prior to joining Ingenuity, Devidas served as vice president of business development and strategy at Jubilant Biosys. Before that, he was vice president of business development and strategy at Strand Genomics.

InforSense has appointed Tidu Maini, pro rector of corporate affairs and development at Imperial College, and John O'Connell, the founder and former chairman and CEO of Staffware, to it board of directors. Maini is responsible for the commercialization of Imperial College's intellectual assets. He was previously senior vice president of Schlumberger. O'Connell led Staffware's IPO in 2000, and currently serves on the board of four high-tech companies.

Atul Butte has joined the Stanford University School of Medicine as an assistant professor in medical informatics and pediatrics. Butte was previously an instructor at Children's Hospital Boston and Harvard Medical School. Butte is also on the scientific advisory board of Genstruct.

Filed under

The Scan

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Following US Food and Drug Administration authorization, the Centers for Disease Control and Prevention has endorsed booster doses of the Moderna and Johnson & Johnson SARS-CoV-2 vaccines, the Washington Post writes.

From a Pig

A genetically modified pig kidney was transplanted into a human without triggering an immune response, Reuters reports.

For Privacy's Sake

Wired reports that more US states are passing genetic privacy laws.

Science Paper on How Poaching Drove Evolution in African Elephants

In Science this week: poaching has led to the rapid evolution of tuskless African elephants.