Solutions: CuraGen Method Derives Signal from Noise in Protein Interaction Maps | GenomeWeb

Following the release of the first protein-protein interaction map for yeast in 2000, a number of similar data sets have become available, promising a valuable source of information for biologists interested in studying individual genes or proteins in the context of their sub-cellular behavior. But these data sets have failed to live up to their promise as discovery tools because they exhibit very high false positive rates: It’s been estimated that only 30 to 50 percent of the interactions depicted in such maps are real.

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