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Rosetta Resolver, ActivityBase 5.3, SARview 6.0., BIND, SMID, AurScope, Pfam 15.0, UniProt, HyPare, BioVL Virtual Lab Bench


Rosetta Biosoftware has launched version 5.0 of the Rosetta Resolver gene expression data analysis system. New features include additional customization capabilities; a similarity search feature; and productivity enhancements.

IDBS has released ActivityBase 5.3 and SARview 6.0. ActivityBase 5.3 includes a new Oracle package and “additional enhancements for biologists,” according to the company, while SARview 6.0 provides different views of the data from within the same application.

The Blueprint Initiative has released version 3.5 of the BIND web interface. The new release includes a dynamic collapsible HTML page and the option of saving and printing out a PDF version of full BIND records. Blueprint also released the Small-Molecule Interaction Database (SMID), which links small molecules to their protein partners and their families.

Paris-based Aureus Pharma has released new versions of its AurScope databases for GPCR and ADME/drug-drug interactions and the initial release of a new AurScope ion channel database product.

Pfam 15.0 is available at and The latest collection of protein domain family alignments contains 7,503 families.

UniProt release 2.5 is now available from the UniProt consortium at The new release contains 1,559,136 entries, including 158,316 UniProt/Swiss-Prot entries and 1,400,820 UniProt/Trembl entries.

HyPare, a new program based on the PARE (predicting association rate enhancement) algorithm, is available from the Weizmann Institute at The software is designed to identify “hotspots” for association, according to its developers, and can be used to engineer proteins for faster and tighter binding.

Biomax has released a free trial version of its BioVL Virtual Lab Bench software at BioVL is a desktop application for graphical representation and in silico manipulation of DNA sequences.

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The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.