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Rosetta Biosoftware, Agilent Technologies, Biomax Informatics, Affymetrix, Genostar, Institute for Systems Biology


Rosetta Biosoftware and Agilent Technologies have jointly launched version 4.0 of the Rosetta Resolver gene expression data analysis system. Among a number of new features, the new version is the first bioinformatics software platform to support compliance with the US FDA’s Code of Federal Regulations (CFR), Part 11, according to the companies. CFR Part 11 requires companies using computerized systems to document and validate all electronic data involved in the research, manufacture, or management of FDA-regulated products. Other new features include visual scripting to automate common tasks, MAGE compatibility, enhanced QA/QC, and a proprietary two-way analysis of variance (ANOVA) algorithm.

Biomax Informatics of Martinsried, Germany, has released version 5.0 of the BioRS Integration and Retrieval System, a software tool for searching biological information from flat-file and relational databases. New features in version 5.0 include enhanced support for XML databases, increased accuracy and efficiency for searching hierarchical structures in databases, improved security, and support for the AIX operating system on IBM platforms.

Affymetrix has released two software products in support of the MAGE-ML standard via its external developers’ network page: www.affymetrix. com/support/developer/index.affx. The first is the GDAC (GeneChip Data Access Components) Exporter SDK (Software Developers Kit), which offers APIs to export data from the Affymetrix Microarray Suite (MAS) and LIMS systems. The second, called Expression Exporter, allows end-users to export Affymetrix data to MAGE-ML compliant files.

The Genostar consortium, which includes Genome Express, Hybrigenics, INRIA, and the Institut Pasteur, released the first version of its bioinformatics platform, Genostar 1.0, which runs under Linux, Unix, and Mac OS X. It is made up of three application modules, GenoAnnot for sequence annotation, GenoLink for comparison of different data types, and GenoBool for data analysis and visualization. Access conditions and licensing terms are available at:

ACGT (A Comparative Genomics Tool), a genomic DNA sequence comparison viewer based on the BioJava 1.21 library, is available from the Institute for Systems Biology at:

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The Scan

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In Science this week: pair of mutations in one gene uncovered in brothers with short stature and immunodeficiency, and more.