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Remo Rohs: Structure and Sequence

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Recommended by: Tom Tullius, Boston University

It was during his postdoctoral work in a computational biology group at Columbia University that Remo Rohs first became convinced that DNA structure and sequence research should be integrated. Now, Rohs is making that a reality with a new method he is developing for high-throughput prediction of DNA shape in his lab at the University of Southern California.

"We applied this approach to the analysis of hundred thousands of sequences derived from SELEX-seq experiments, and discovered evolutionary relationships in DNA shape," Rohs says. "I would like my laboratory to be known as the lab that achieved the intellectual breakthrough of analyzing high-throughput sequencing data for three-dimensional DNA shape information. I want my lab to be part of the discovery of a variety of biological mechanisms based on the integration of sequence and shape."

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