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IP Update: Sep 16, 2011


Recent Patents in Bioinformatics, August — September 2011

US Patent 8,019,553. Method of modeling for drug design, evaluation, and prescription in the treatment of disease. Inventor: Michael Goldstein.

Describes an immunodynamic model that simulates the interactions between infection, immune response, and treatment in infectious diseases.

US Patent 8,014,953. RNA surveillance among curated proteins. Inventors: Steven E. Brenner, Richard E. Green, Tyler R. Hillman. Assignee: The Regents of the University of California.

The patent describes computational methods for characterizing putative protein isoforms as targets of nonsense-mediated decay. The program is used to identify mRNA sequences that represent transcripts that encode a set of protein isoforms; determine the corresponding gene intron-exon structures by mapping the mRNA sequences to their corresponding genomic sequences; and then determine if the transcripts are targets of NMD.

US Patent 8,005,627. Bioinformatic approach to disease diagnosis. Inventor: Richard Porwancher.

Describes a method of constructing a multivariate predictive model to diagnose disease using results from multiple diagnostic tests. The system involves selecting tests to include in a diagnostic panel. It uses an algorithm to weight the results of each test and generate a likelihood ratio, and then uses a clinical algorithm to estimate the pre-test probability of the disease based on clinical signs and symptoms. Finally, it combines both values to generate a post-test probability of the disease, which is compared to a cutoff value.

US Patent 8,005,626. System and computer readable medium for discovering gene regulatory models and genetic networks using relational fuzzy models. Inventors: Bhooshan P. Kelkar, Rajiv D. Bendale. Assignee: IBM.

Describes a system for building relational fuzzy models from sets of genes. The approach includes a data-selection method that clusters gene expression data and identifies a representative subset of genes and then uses a relational fuzzy modeling system to build a model of the gene set.

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The Scan

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.

TB Resistance Insights Gleaned From Genome Sequence, Antimicrobial Response Assays

Researchers in PLOS Biology explore M. tuberculosis resistance with a combination of sequencing and assays looking at the minimum inhibitory concentrations of 13 drugs.

Mendelian Disease Genes Prioritized Using Tissue-Specific Expression Clues

Mendelian gene candidates could be flagged for further functional analyses based on tissue-specific transcriptome and proteome profiles, a new Journal of Human Genetics paper says.

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.