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IP Update: Sep 16, 2011


Recent Patents in Bioinformatics, August — September 2011

US Patent 8,019,553. Method of modeling for drug design, evaluation, and prescription in the treatment of disease. Inventor: Michael Goldstein.

Describes an immunodynamic model that simulates the interactions between infection, immune response, and treatment in infectious diseases.

US Patent 8,014,953. RNA surveillance among curated proteins. Inventors: Steven E. Brenner, Richard E. Green, Tyler R. Hillman. Assignee: The Regents of the University of California.

The patent describes computational methods for characterizing putative protein isoforms as targets of nonsense-mediated decay. The program is used to identify mRNA sequences that represent transcripts that encode a set of protein isoforms; determine the corresponding gene intron-exon structures by mapping the mRNA sequences to their corresponding genomic sequences; and then determine if the transcripts are targets of NMD.

US Patent 8,005,627. Bioinformatic approach to disease diagnosis. Inventor: Richard Porwancher.

Describes a method of constructing a multivariate predictive model to diagnose disease using results from multiple diagnostic tests. The system involves selecting tests to include in a diagnostic panel. It uses an algorithm to weight the results of each test and generate a likelihood ratio, and then uses a clinical algorithm to estimate the pre-test probability of the disease based on clinical signs and symptoms. Finally, it combines both values to generate a post-test probability of the disease, which is compared to a cutoff value.

US Patent 8,005,626. System and computer readable medium for discovering gene regulatory models and genetic networks using relational fuzzy models. Inventors: Bhooshan P. Kelkar, Rajiv D. Bendale. Assignee: IBM.

Describes a system for building relational fuzzy models from sets of genes. The approach includes a data-selection method that clusters gene expression data and identifies a representative subset of genes and then uses a relational fuzzy modeling system to build a model of the gene set.

Filed under

The Scan

And Back

The New York Times reports that missing SARS-CoV-2 genome sequences are back in a different database.

Lacks Family Hires Attorney

A lawyer for the family of Henrietta Lacks plans to seek compensation from pharmaceutical companies that have used her cancer cells in product development, the Baltimore Sun reports.

For the Unknown

The Associated Press reports that family members are calling on the US military to use new DNA analysis techniques to identify unknown sailors and Marines who were on the USS Arizona.

PLOS Papers on Congenital Heart Disease, COVID-19 Infection Host MicroRNAs, Multiple Malformation Mutations

In PLOS this week: new genes linked to congenital heart disease, microRNAs with altered expression in COVID-19, and more.