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IP Update: Sep 16, 2011


Recent Patents in Bioinformatics, August — September 2011

US Patent 8,019,553. Method of modeling for drug design, evaluation, and prescription in the treatment of disease. Inventor: Michael Goldstein.

Describes an immunodynamic model that simulates the interactions between infection, immune response, and treatment in infectious diseases.

US Patent 8,014,953. RNA surveillance among curated proteins. Inventors: Steven E. Brenner, Richard E. Green, Tyler R. Hillman. Assignee: The Regents of the University of California.

The patent describes computational methods for characterizing putative protein isoforms as targets of nonsense-mediated decay. The program is used to identify mRNA sequences that represent transcripts that encode a set of protein isoforms; determine the corresponding gene intron-exon structures by mapping the mRNA sequences to their corresponding genomic sequences; and then determine if the transcripts are targets of NMD.

US Patent 8,005,627. Bioinformatic approach to disease diagnosis. Inventor: Richard Porwancher.

Describes a method of constructing a multivariate predictive model to diagnose disease using results from multiple diagnostic tests. The system involves selecting tests to include in a diagnostic panel. It uses an algorithm to weight the results of each test and generate a likelihood ratio, and then uses a clinical algorithm to estimate the pre-test probability of the disease based on clinical signs and symptoms. Finally, it combines both values to generate a post-test probability of the disease, which is compared to a cutoff value.

US Patent 8,005,626. System and computer readable medium for discovering gene regulatory models and genetic networks using relational fuzzy models. Inventors: Bhooshan P. Kelkar, Rajiv D. Bendale. Assignee: IBM.

Describes a system for building relational fuzzy models from sets of genes. The approach includes a data-selection method that clusters gene expression data and identifies a representative subset of genes and then uses a relational fuzzy modeling system to build a model of the gene set.

Filed under

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.