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Reactome version 19, FABLE, CCP4 version 6.0.2

Reactome version 19 is currently available here. The latest version of the curated knowledgebase of biological processes in humans includes modules for Uncoating, Reverse Transcription, and Integration under HIV Life Cycle as well as other new modules. Reactome data can be exported in SMBL, Protégé, and BioPAX level 2 formats.

FABLE (Fast Automated Biomedical Literature Extraction) version 2.0 is available here. FABLE performs document retrieval and gene list extractions of Medline abstracts for queries of genes, transcripts, and proteins by annotating text in an automated process. New features include a "Gene Lister" application that allows users to create lists of relevant human genes from the biomedical literature by entering arbitrary Boolean keyword searches. In addition, for all search results, users can now click next to the listed gene symbol to see all synonyms for the symbol.

CCP4 version 6.0.2 is available here. The release contains several bug fixes and program updates. CCP4mg has been updated to version 1.0 and Coot to version 0.1.2. Several major new programs are also available on the CCP4 pre-release page.

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The Scan

Study Reveals New Details About Genetics of Major Cause of Female Infertility

Researchers in Nature Medicine conducted a whole-exome sequencing study of mote than a thousand patients with premature ovarian insufficiency.

Circulating Tumor DNA Shows Potential as Biomarker in Rare Childhood Cancer

A study in the Journal of Clinical Oncology has found that circulating tumor DNA levels in rhabdomyosarcoma may serve as a biomarker for prognosis.

Study Recommends Cancer Screening for Dogs Beginning Age Seven, Depending on Breed

PetDx researchers report in PLOS One that annual cancer screening for dogs should begin by age seven.

White-Tailed Deer Harbor SARS-CoV-2 Variants No Longer Infecting Humans, Study Finds

A new study in PNAS has found that white-tailed deer could act as a reservoir of SARS-CoV-2 variants no longer found among humans.