Bench biologists cull information for Reactome, editing and managing it as a relational database. New material is peer-reviewed and revised before publication to the web. Reactome entries are linked to Entrez Gene, RefSeq, OMIM, Ensembl genome annotations, HapMap, the University of California Santa Cruz Genome Browser, KEGG, ChEBI, and the Gene Ontology.
New topics in Version 21 include the Rho GTPase cycle, Wnt regulation of beta-catenin, gap junction turnover, pathways for steroid hormone biosynthesis, metabolism of bile acids and bile salts, and snRNP assembly. In addition, an outline of the influenza virus infection cycle is also available.