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Reactome Knowledgebase, Genevestigator

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Version 21 of the Reactome Knowledgebase is available here. The curated knowledgebase covers human biological processes ranging from metabolic pathways to hormonal signaling and apoptosis.

Bench biologists cull information for Reactome, editing and managing it as a relational database. New material is peer-reviewed and revised before publication to the web. Reactome entries are linked to Entrez Gene, RefSeq, OMIM, Ensembl genome annotations, HapMap, the University of California Santa Cruz Genome Browser, KEGG, ChEBI, and the Gene Ontology.

New topics in Version 21 include the Rho GTPase cycle, Wnt regulation of beta-catenin, gap junction turnover, pathways for steroid hormone biosynthesis, metabolism of bile acids and bile salts, and snRNP assembly. In addition, an outline of the influenza virus infection cycle is also available.

 

 
The Swiss Federal Institute of Technology has released version 3 of Genevestigator, a microarray database and discovery platform. The new release includes more than 10,000 curated Affymetrix arrays for rat, mouse, and Arabidopsis.  

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The Scan

Could Mix It Up

The US Food and Drug Administration is considering a plan that would allow for the mixing-and-matching of SARS-CoV-2 vaccines and boosters, the New York Times says.

Closest to the Dog

New Scientist reports that extinct Japanese wolf appears to be the closest known wild relative of dogs.

Offer to Come Back

The Knoxville News Sentinel reports that the University of Tennessee is offering Anming Hu, a professor who was acquitted of charges that he hid ties to China, his position back.

PNAS Papers on Myeloid Differentiation MicroRNAs, Urinary Exosomes, Maize Domestication

In PNAS this week: role of microRNAs in myeloid differentiation, exosomes in urine, and more.