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Reactome Knowledgebase, Genevestigator

Version 21 of the Reactome Knowledgebase is available here. The curated knowledgebase covers human biological processes ranging from metabolic pathways to hormonal signaling and apoptosis.

Bench biologists cull information for Reactome, editing and managing it as a relational database. New material is peer-reviewed and revised before publication to the web. Reactome entries are linked to Entrez Gene, RefSeq, OMIM, Ensembl genome annotations, HapMap, the University of California Santa Cruz Genome Browser, KEGG, ChEBI, and the Gene Ontology.

New topics in Version 21 include the Rho GTPase cycle, Wnt regulation of beta-catenin, gap junction turnover, pathways for steroid hormone biosynthesis, metabolism of bile acids and bile salts, and snRNP assembly. In addition, an outline of the influenza virus infection cycle is also available.


The Swiss Federal Institute of Technology has released version 3 of Genevestigator, a microarray database and discovery platform. The new release includes more than 10,000 curated Affymetrix arrays for rat, mouse, and Arabidopsis.  

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The Scan

US Supports Patent Waivers

NPR reports that the Biden Administration has announced its support for waiving intellectual property protections for SARS-CoV-2 vaccines.

Vaccines Versus Variants

Two studies find the Pfizer-BioNTech SARS-CoV-2 vaccine to be effective against viral variants, and Moderna reports on booster shots to combat variants.

CRISPR for What Ails You

The Wall Street Journal writes that CRISPR-based therapies could someday be used to treat common conditions like heart attacks.

Nature Papers Review Integration of Single-Cell Assay Data, Present Approach to Detect Rare Variants

In Nature this week: review of ways to integrate data from single-cell assays, and more.