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Reactome Knowledgebase, Genevestigator

Version 21 of the Reactome Knowledgebase is available here. The curated knowledgebase covers human biological processes ranging from metabolic pathways to hormonal signaling and apoptosis.

Bench biologists cull information for Reactome, editing and managing it as a relational database. New material is peer-reviewed and revised before publication to the web. Reactome entries are linked to Entrez Gene, RefSeq, OMIM, Ensembl genome annotations, HapMap, the University of California Santa Cruz Genome Browser, KEGG, ChEBI, and the Gene Ontology.

New topics in Version 21 include the Rho GTPase cycle, Wnt regulation of beta-catenin, gap junction turnover, pathways for steroid hormone biosynthesis, metabolism of bile acids and bile salts, and snRNP assembly. In addition, an outline of the influenza virus infection cycle is also available.


The Swiss Federal Institute of Technology has released version 3 of Genevestigator, a microarray database and discovery platform. The new release includes more than 10,000 curated Affymetrix arrays for rat, mouse, and Arabidopsis.  

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The Scan

Latent HIV Found in White Blood Cells of Individuals on Long-Term Treatments

Researchers in Nature Microbiology find HIV genetic material in monocyte white blood cells and in macrophages that differentiated from them in individuals on HIV-suppressive treatment.

Seagull Microbiome Altered by Microplastic Exposure

The overall diversity and the composition at gut microbiome sites appear to coincide with microplastic exposure and ingestion in two wild bird species, according to a new Nature Ecology and Evolution study.

Study Traces Bladder Cancer Risk Contributors in Organ Transplant Recipients

In eLife, genome and transcriptome sequencing reveal mutation signatures, recurrent somatic mutations, and risky virus sequences in bladder cancers occurring in transplant recipients.

Genes Linked to White-Tailed Jackrabbits' Winter Coat Color Change

Climate change, the researchers noted in Science, may lead to camouflage mismatch and increase predation of white-tailed jackrabbits.