Facing an opportunity that would make many informatics managers green with envy — building an IT infrastructure from scratch without the burden of legacy tools or data — Les Klimczak was careful not to take his good fortune for granted. When designing the informatics system for Gaithersburg, Md.-based drug discovery startup Psychiatric Genomics, Klimczak said he took extra steps to ensure that it could grow and adapt as the small company’s needs change.

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