"Genetic Toggle Switch" Developed at Boston Univ.

Jan 27, 2000

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OSTON--Boston University scientists have created what they say is the first synthetic "genetic toggle switch" to control the activity of genes. Working with E. coli bacteria, researchers at the university’s Center for BioDynamics and Department of Biomedical Engineering were able to switch the expression of genes between stable on and off states by applying a brief chemical or temperature stimulus. The work is reported in the January 20 issue of Nature.

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