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PubChem, Ingenuity, InforSense, Nonlinear Dynamics, ViaGen, AgInfoLink, Mouse Phenotyping Bioinformatics


House Bill Poses No Restrictions on
PubChem, Calls for Compromise

A US House of Representatives appropriations subcommittee last week addressed an ongoing dispute between the American Chemical Society and the National Institutes of Health regarding NIH's PubChem small-molecule repository, which ACS claims duplicates its subscription-based Chemical Abstracts Service.

In a report accompanying the appropriations bill — in which it approved a 5 percent increase on the 2006 NIH budget, to $28.5 billion — the House Appropriations Labor/Health and Human Services/Education subcommittee noted that PubChem's role is to "house both compound information from the scientific literature as well as" data from the NIH Molecular Libraries Initiative.

ACS has contended that PubChem overstepped its bounds by including information in PubChem that was not generated by the Molecular Libraries Initiative [BioInform 05-16-05]. ACS Appealed to Ohio Congressman Ralph Regula, chair of the subcommittee, to discuss whether the House bill should address the dispute. CAS is headquartered in Ohio.

But despite concerns that the subcommittee would limit funding for PubChem [BioInform 05-30-05], the subcommittee report only "urges NIH to work with private sector providers to avoid unnecessary duplication and competition."

According to a report in this week's Science, ACS said it is "very pleased" with the subcommittee's recommendation, and expects" to work diligently with NIH toward a collaborative model."

Serono Licenses Ingenuity's Pathway
Knowledge Base, Analysis Software

Ingenuity said last week that the Serono Genetics Institute has licensed its Pathways Knowledge Base, a manually curated database created from millions of relationships between proteins, genes, complexes, cells, tissues, drugs, and diseases.

Serono also licensed Ingenuity Pathways Analysis, the company's pathway analysis application.

Financial terms for the licensing agreement were not disclosed.

Biogen Idec to Use InforSense KDE and TextSense

InforSense said last week that Biogen Idec has licensed InforSense KDE, its workflow software platform, as well as its TextSense text-mining technology.

Terms of the agreement were not disclosed.

Australian Proteome Analysis Facility
To Use Nonlinear's Progenesis

Nonlinear Dynamics said last week that the Australian Proteome Analysis Facility has purchased two licenses of its Progenesis Discovery 2D gel image analysis platform.

Financial terms were not disclosed for the purchase, which was funded through the Australian Major National Research Facilities Program.

ViaGen, AgInfoLink to Co-develop
Genetic Data Storage System for Livestock

ViaGen, an animal genomics firm, and AgInfoLink, a provider of agricultural information management systems, are co-developing a data storage system to track genetic information for livestock, the companies said last week.

The web-based system, which will allow "producers, ranchers, feedlot managers and others associated with the beef industry to collect, sort, analyze and store genetic information instantly," is expected to be available by the end of the summer, the companies said.

The data system will provide storage and dissemination for ViaGen's genetic tests and programs, which include AnguSure for verifying branded beef labels, Inducator for analyzing Brahman composition, and BreedSure and KwikBreed for confirming breed classification.

NIH Earmarks up to $4M over Five Years
for Mouse Phenotyping Bioinformatics

The National Institute of Diabetes and Digestive and Kidney Diseases plans to provide up to $4 million over five years to support a bioinformatics unit for a consortium of mouse metabolic phenotyping centers.

In a request for applications issued last Friday, entitled, "Coordinating and Bioinformatics Unit for the Mouse Metabolic Phenotyping Centers and Animal Models of Diabetic Complications Consortium," NIDDK said that the bioinformatics unit will develop, house, and maintain the websites and databases for a network of four national Mouse Metabolic Phenotyping Centers.

NIDDK said it will award the bioinformatics unit up to $1 million for the first year and $750,000 for each of four additional years.

The phenotyping centers, outlined in a separate RFA, will be granted a total of $4.2 million for each of five years. They will conduct detailed metabolic phenotyping of genetically altered mice and other mouse models that are useful for understanding diabetes and its complications, obesity, and related metabolic diseases or conditions.

The bioinformatics unit will also "carry out administrative tasks and organize both separate and joint meetings" for the consortium, NIDDK said.

Letters of intent are due Oct. 18, and applications are due Nov. 16.

The RFA is available at


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